Evidence map›Paper›PMID 37655275›Full record

ArticleCytotechnology2023

H3K27 acetylation-induced FSTL1 upregulation by P300/RUNX1 co-activation exacerbated autophagy-mediated neuronal damage and NF-κB-stimulated inflammation in Alzheimer's disease.

Dongmei Dai, Junzheng Xie, Yun Zheng, Fangbin Chen, Bin Zhao, Li Miao

Open access · greenAbstract read
In one paragraph

Article in Cytotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dongmei Dai *Department of Psychiatry, 904th Hospital of Joint Logistic Support Force of PLA, No. 55, Heping North Rd., Tianning District, Changzhou, 213000 Jiangsu China.
Junzheng Xie *Department of Psychiatry, 904th Hospital of Joint Logistic Support Force of PLA, No. 55, Heping North Rd., Tianning District, Changzhou, 213000 Jiangsu China.
Yun ZhengDepartment of Psychiatry, 904th Hospital of Joint Logistic Support Force of PLA, No. 55, Heping North Rd., Tianning District, Changzhou, 213000 Jiangsu China.
Fangbin ChenDepartment of Psychiatry, 904th Hospital of Joint Logistic Support Force of PLA, No. 55, Heping North Rd., Tianning District, Changzhou, 213000 Jiangsu China.
Bin ZhaoDepartment of Material Dependency, 904th Hospital of Joint Logistic Support Force of PLA, Changzhou, China.
Li MiaoDepartment of Material Dependency, 904th Hospital of Joint Logistic Support Force of PLA, Changzhou, China.
81th Hospital of PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follistatin-like protein 1 (FSTL1) has been demonstrated to participate in the pathogenesis of several neurological diseases. The current study informed the role of H3K27 acetylation-induced FSTL1 upregulation in Alzheimer's disease (AD). Our investigation discovered the upregulated FSTL1 expression and enhanced autophagy activity in AD. FSTL1 knockdown successfully attenuated the injuries of Aβ

Indexed as

Alzheimer’s diseaseAutophagyFSTL1H3K27 acetylationInflammation

Identifiers

PMID37655275
PMCPMC10465437
OpenAlexW4385580832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.