Evidence map›Paper›PMID 37655224›Full record

ArticleNature cardiovascular research2023

Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter.

Anish V Sharda, Sean X Gu, John Hwa

Open access · greenAbstract read
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anish V ShardaSection of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Sean X GuDepartment of Laboratory Medicine, Yale University School of Medicine, Yale New Haven Hospital, New Haven, CT, USA.ORCID 0000-0001-5505-3474
John HwaYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7366-2628
Yale University · USYale New Haven Hospital · US

Funding

Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7M
IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
Hyperglycemia, thromboxane and platelet activity in diabetes mellitusR01HL115247 · NHLBI · YALE UNIVERSITY · PI HWA, JOHN · 2012 to 2019
$3.8M
Platelet Mitochondrial Function in Health and DiseaseR01HL122815 · NHLBI · YALE UNIVERSITY · PI HWA, JOHN · 2015 to 2023
$3.7M
Platelets in vascular injury repairR01HL150515 · NHLBI · YALE UNIVERSITY · PI HWA, JOHN · 2020 to 2023
$2.3M
Molecular Mechanisms Underlying Endothelial Weibel-Palade Body Biogenesis and ExocytosisK08HL150246 · NHLBI · YALE UNIVERSITY · PI SHARDA, ANISH VAIBHAV · 2021 to 2025
$901k
NHLBI NIH HHS K08 HL150246NHLBI NIH HHS R01 HL115247NHLBI NIH HHS R01 HL122815NHLBI NIH HHS R01 HL150515NHLBI NIH HHS T32 HL007974NIDDK NIH HHS U54 DK106857
6 · The paper itself

Abstract

Structural determination of the ABCC4 transporter is a major first step in providing crucial molecular insights into the transport of platelet substrates into granules, as well as drug transport from platelets. The findings provide a framework for understanding platelet interactions and potential design of specific platelet antagonists.

Identifiers

PMID37655224
PMCPMC10470688
OpenAlexW4381190317

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.