ArticleGeneral psychiatry2023
Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review.
Article in General psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- What are the correlates of non-suicidal self-injury in children and adolescents? An umbrella systematic review of global evidence.Molecular psychiatry · 2026Pooled it
- Interventions for suicidal and self-injurious related behaviors in adolescents with psychiatric disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- Gray matter volume alterations in early-adulthood major depressive disorder patients with non-suicidal self-injury and suicide attempts.BMC psychiatry · 2026Article
- Exercise type, dose and mental health outcomes in youth: Which types and doses are sufficient?General psychiatry · 2026Article
- Predictive utility and associated challenges of adolescent arm scarring in suicide risk assessment.BMC psychiatry · 2026Article
- Unmasking the "Mixed-Dysregulated" phenotype: latent profiles of affective temperaments and non-suicidal self-injury in adolescents with depression.BMC psychiatry · 2026Article
- Decreased anticipatory and consummatory pleasure in adolescents with non-suicidal self-injury and its association with suicidal attempt.Child and adolescent psychiatry and mental health · 2026Article
- The Influence of Dark Triad Traits on Non-Suicidal Self-Injury Among Left-Behind Adolescents: A Moderated Mediation Model.Behavioral sciences (Basel, Switzerland) · 2026Article
- Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- Association between nonsuicidal self-injury and borderline personality features in early-adolescent students: a cross-sectional study.Annals of medicine and surgery (2012) · 2026Article
- Childhood maltreatment and adolescent non-suicidal self-injury: cross-sectional conditional process and network analyses of depressive symptoms and physical activity.Frontiers in psychiatry · 2026Article
- Machine learning-based nomogram for non-suicidal self-injury among depressed adolescents: a multicentre study.Frontiers in psychiatry · 2026Article
- Research progress on the characteristic features of non-suicidal self-injury addiction, neuroimaging correlates, and evidence-based interventions in adolescents.Frontiers in psychology · 2026Review
- Altered brain function associated with non-suicidal self-injury in adolescents with major depressive disorder: An rs-fMRI study.PloS one · 2026Article
- Longitudinal association between negative life events and depression among Chinese senior high school students: the mediating role of psychological inflexibility and the moderating role of meaning in life.Frontiers in public health · 2026Article
- Structural covariance network in the striatum is modulated by non-suicidal self-injury in adolescents with major depressive disorder.BMC psychiatry · 2025Article
- First evaluation of the emotional picture set of self-injury images (EPSI) using psychophysiological and self-report measures.Borderline personality disorder and emotion dysregulation · 2025Article
- The Relationship Between Parental Psychological Control and College Students' Non-Suicidal Self-Injury: The Chain Mediation Roles of Relative Deprivation and Depression and the Moderating Role of Peer Relationships.Behavioral sciences (Basel, Switzerland) · 2025Article
- Development and validation of a probability-assessment nomogram for non-suicidal self-injury in hospitalized adolescents and young adults with mental disorders.Scientific reports · 2025Article
- Altered local gyrification index and corresponding functional connectivity in female depressed adolescents with suicide attempts and non-suicidal self-injury.Psychoradiology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Non-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence and risk factors are relatively well understood, the potential mechanisms of NSSI in MDD remain elusive. Aims: To review present evidence related to the potential mechanisms of NSSI in MDD. Methods: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, articles for this systematic review were searched on Medline (through PubMed), Embase (through Elsevier), PsycINFO (through OVID) and Web of Science databases for English articles, as well as China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang Data, and the Chongqing VIP Chinese Science and Technology Periodical (VIP) Databases for Chinese articles published from the date of inception to 2 August 2022. Two researchers (BW, HZ) independently screened studies based on inclusion and exclusion criteria and assessed their quality. Results: A total of 25 157 studies were searched. Only 25 of them were ultimately included, containing 3336 subjects (1535 patients with MDD and NSSI, 1403 patients with MDD without NSSI and 398 HCs). Included studies were divided into 6 categories: psychosocial factors (11 studies), neuroimaging (8 studies), stress and hypothalamic-pituitary-adrenal (HPA) axis (2 studies), pain perception (1 study), electroencephalogram (EEG) (2 studies) and epigenetics (1 study). Conclusions: This systematic review indicates that patients with MDD and NSSI might have specific psychosocial factors, aberrant brain functions and neurochemical metabolisms, HPA axis dysfunctions, abnormal pain perceptions and epigenetic alterations.
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