ArticleFrontiers in psychiatry2023
Association between constipation and major depression in adult Americans: evidence from NHANES 2005-2010.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Constipation is associated with an increased risk of depression: A systematic review and meta-analysis of observational studies.Translational psychiatry · 2026Pooled it
- Clinical efficacy of non-pharmacological treatment of functional constipation: a systematic review and network meta-analysis.Frontiers in cellular and infection microbiology · 2025Pooled it
- Association between A Body Shape Index with constipation and diarrhea: NHANES 2005 to 2010.Medicine · 2026Article
- Relationship Between Depression and Constipation: A Cross-Sectional Health Report From the PERSIAN Guilan Cohort Study (PGCS).Health science reports · 2026Article
- Associations between five anthropometric indices and fecal incontinence: A cross-sectional study based on the 2005 to 2010 NHANES data.Medicine · 2026Article
- Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.Brain and behavior · 2026Article
- Postmarketing surveillance of elobixibat for patients with chronic constipation and concomitant schizophrenia or depression in Japan.Frontiers in psychiatry · 2026Article
- The microbiota-gut-brain axis perspective: mechanisms and intervention strategies for the comorbidity of chronic constipation and depression.Frontiers in microbiology · 2026Review
- Clinical characteristics and associated factors of constipation patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Gut-Brain Axis in Comorbid Constipation and Mood Disorders: Navigating the Efficacy-Tolerability Dilemma Through Emerging Evidence and Future Directions.International journal of general medicine · 2026Review
- Sex-specific transcriptome similarity networks elucidate comorbidity relationships.Communications medicine · 2025Article
- Pathophysiological mechanisms, diagnostic innovations, and multimodal therapeutic strategies for slow transit constipation.BMC gastroenterology · 2025Review
- Effect of Chronic Social Defeat Stress on the Small-Intestinal Environment, Including the Gut Flora, Immune System, and Mucosal Barrier Integrity.International journal of molecular sciences · 2025Article
- Combined association of chewing capacity and depression with constipation: a cross-sectional study.BMC gastroenterology · 2025Article
- Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders.World journal of clinical pediatrics · 2025Article
- Association between resolved hepatitis B virus infection and depression in American adults : a cross-sectional study.Scientific reports · 2025Article
- Association of constipation with suicidal ideation among US adults and the partial mediating role of depression.Scientific reports · 2025Article
- Association between atherogenic index of plasma and chronic diarrhea: a cross-sectional study of the NHANES 2005-2010.BMC gastroenterology · 2025Article
- Health Effects of Plant-Based Diets in University Life: A Comprehensive Study on the Constipation, Sleep and Obesity.Iranian journal of public health · 2025Article
- Daily sodium intake and constipation in US adult males: an uncommon negative association revealed by national health and nutrition examination survey data from the United States (2005-2010).BMC gastroenterology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Current studies on the association between constipation and depression is still insufficient. In this study, we investigated the detailed association between constipation and major depression among American adults. Methods: In this cross-sectional study, 12,352 adults aged 20 and older were selected from the National Health and Nutrition Examination Survey 2005-2010 for the sample. Constipation was defined as fewer than three defecation frequencies per week. For the assessment of major depression, the validated Patient Health Questionnaire-9 was used. Adjusted odds ratios (ORs) were calculated using multivariate logistic regression models. A subgroup analysis was carried out to ensure that the results were stable. Results: Of the 12,352 participants, 430 reported constipation, with a prevalence of 3.5%. Depression was reported in 1030 cases, indicating a prevalence rate of 8.3%. Patients with constipation were significantly more likely to have major depression (20.9%) than those without it (7.9%, Conclusion: In conclusion, this study showed that constipation were significantly associated with depression. When treating patients with constipation, it is necessary for clinicians to screen and evaluate depression, and provide timely and effective intervention for patients with depression to avoid further deterioration of the condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.