Evidence map›Paper›PMID 37654976›Full record

ArticleJournal of environmental science and public health2023

Elevated Maternal Testosterone Levels Alter PFOA Elimination and Tissue Distribution in Pregnant Rats.

Pankaj Yadav, Jay S Mishra, Sathish Kumar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of environmental science and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pankaj YadavDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Jay S MishraDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Sathish KumarDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
University of Wisconsin–Madison · US

Funding

Per- and poly-fluoroalkyl substances (PFAS) in pregnancy vascular and placental dysfunctionR01ES033345 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI SATHISH KUMAR · 2022 to 2026
$1.7M
Vascular AT2R expression and function during pregnancyR01HL134779 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI KUMAR, SATHISH · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL134779NIEHS NIH HHS R01 ES033345
6 · The paper itself

Abstract

Perfluorooctanoic acid (PFOA) is an enduring synthetic chemical that harms human health. Recent studies indicate heightened bioaccumulation of PFOA, particularly in pregnant women experiencing preeclampsia. Since plasma testosterone levels are elevated in pregnant women with preeclampsia, we hypothesized that hyperandrogenic conditions during pregnancy may hinder PFOA elimination and contribute to their higher body burden. Pregnant Sprague-Dawley rats were s/c injected with vehicle or testosterone propionate from gestational day (GD) 15 to 20 to increase plasma testosterone levels by 2-fold, similar to levels in preeclampsia. On GD 16, [

Indexed as

BioaccumulationKidneyPerfluorooctanoic acidPregnant ratsTestosteroneTransporters

Identifiers

PMID37654976
PMCPMC10470210
OpenAlexW4385710933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.