Evidence map›Paper›PMID 37654682›Full record

ArticleTransplantation direct2023

Delayed Graft Function Among Kidney Transplant Recipients Is Associated With an Increased Risk of Urinary Tract Infection and BK Viremia.

Eman A Alshaikh, Brad C Astor, Brenda Muth, Margaret Jorgenson, Kurt Swanson, Neetika Garg, Fahad Aziz, Maha Mohamed, Didier Mandelbrot, Sandesh Parajuli

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eman A AlshaikhDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Brad C AstorDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Brenda MuthDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Margaret JorgensonDepartment of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI.
Kurt SwansonDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Neetika GargDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Fahad AzizDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Maha MohamedDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Didier MandelbrotDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Sandesh ParajuliDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
University of Wisconsin–Madison · USUW Health University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Delayed graft function (DGF) among deceased donor kidney transplant recipients (DDKTRs) is a well-known risk factor for allograft rejection, decreased graft survival, and increased cost. Although DGF is associated with an increased risk of rejection, it is unclear whether it also increases the risk of infection. Methods: We reviewed all adult DDKTRs at our center between 2010 and 2018. The primary outcomes of interest were BK viremia, cytomegalovirus viremia, pneumonia, and urinary tract infection (UTI) within the first year of transplant. Additional analysis was made with censoring follow-up at the time of allograft rejection. Results: A total of 1512 DDKTRs were included, of whom 468 (31%) had DGF. As expected, several recipient, donor, and baseline immunological characteristics differed by DGF status. After adjustment, DGF was significantly associated with an increased risk of BK viremia (hazard ratio: 1.34; 95% confidence interval, 1.0-1.81; Conclusions: DGF is associated with an increased risk of early infectious complications, mainly UTI and BK viremia. Close monitoring and appropriate management are warranted for better outcomes in this unique population.

Identifiers

PMID37654682
PMCPMC10466499
OpenAlexW4386252732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.