Evidence map›Paper›PMID 37654486›Full record

ReviewFrontiers in immunology2023

Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma.

Mitchell N Lefebvre, Nicholas Borcherding, Ryan J Reis, Eric Mou, Vincent Liu, Ali Jabbari

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mitchell N LefebvreUniversity of Iowa Carver College of Medicine, Iowa City, IA, United States.
Nicholas BorcherdingDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Ryan J ReisUniversity of Iowa Carver College of Medicine, Iowa City, IA, United States.
Eric MouDepartment of Hematology and Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.
Vincent LiuUniversity of Iowa Carver College of Medicine, Iowa City, IA, United States.
Ali JabbariUniversity of Iowa Carver College of Medicine, Iowa City, IA, United States.
University of Iowa · USUniversity of Iowa Hospitals and Clinics · USWashington University in St. Louis · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
IL-27 and downstream mechanisms in Alopecia AreataR01AR077194 · NIAMS · UNIVERSITY OF IOWA · PI JABBARI, ALI · 2021 to 2025
$1.7M
Determining the role of T cell effector functions in Alopecia AreataI01BX004907 · VA · IOWA CITY VA MEDICAL CENTER · PI JABBARI, ALI · 2020 to 2023
–
BLRD VA I01 BX004907NCI NIH HHS P30 CA086862NIAMS NIH HHS R01 AR077194NIGMS NIH HHS T32 GM139776
6 · The paper itself

Abstract

Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective and standardized diagnostic and prognostic clinical tools. Currently, diagnosis of CTCL practically relies on clinical presentation, histopathology, and immunohistochemistry. These methods are collectively fraught with limitations in sensitivity and specificity. Fortunately, recent advances in flow cytometry, polymerase chain reaction, high throughput sequencing, and other molecular techniques have shown promise in improving diagnosis and treatment of CTCL. Examples of these advances include T cell receptor clonotyping via sequencing to detect CTCL earlier in the disease course and single-cell RNA sequencing to identify gene expression patterns that commonly drive CTCL pathogenesis. Experience with these techniques has afforded novel insights which may translate into enhanced diagnostic and therapeutic approaches for CTCL.

Indexed as

Lymphoma, Non-HodgkinLymphoma, T-Cell, CutaneousSkin NeoplasmsDisease ProgressionHumansSkincutaneous T cell lymphomaflow cytometryhigh throughput sequencingRNA sequencingTCR - T cell receptor

Identifiers

PMID37654486
PMCPMC10465366
OpenAlexW4385953563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.