Evidence map›Paper›PMID 37654197›Full record

ArticleInternational journal of oncology2023

RYBP contributes to improved prognosis in colorectal cancer via regulation of cell cycle, apoptosis and oxaliplatin sensitivity.

Takashi Morinaka, Nozomu Sakai, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Gaku Ohira, Hisahiro Matsubara, Masayuki Ohtsuka

Open access · hybridAbstract read
In one paragraph

Article in International journal of oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. hsa_circ_0000520 Serves as a Prognostic Biomarker for Colorectal Cancer and Promotes in the Disease Progression.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takashi MorinakaDepartment of General Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Nozomu SakaiDepartment of General Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Tsukasa TakayashikiDepartment of General Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Satoshi KubokiDepartment of General Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Shigetsugu TakanoDepartment of General Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Gaku OhiraDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Hisahiro MatsubaraDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Masayuki OhtsukaDepartment of General Frontier Surgery, Graduate School of Medicine, Chiba University, Chuo, Chiba 260‑8670, Japan.
Chiba University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ring1 and YY‑1 binding protein (RYBP) is a member of the polycomb repressive complex 1 and serves as a transcriptional suppressor via epigenetic modification. RYBP has a tumour‑suppressive role in solid tumours, but its function in colorectal cancer (CRC) remains unknown. The present study evaluated the expression of RYBP using immunohistochemistry in 140 cases of primary CRC and 11 patient‑matched cases of liver metastases. Using CRC cell lines with different

Indexed as

ApoptosisColorectal NeoplasmsCell CycleHumansOxaliplatinPrognosisRepressor ProteinsOxaliplatinRepressor ProteinsRYBP protein, humanapoptosiscell cyclechemo‑ resistanceRYBPtumour suppressor

Identifiers

PMID37654197
PMCPMC10546375
OpenAlexW4386308118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.