ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Toward digitally screening and profiling AD: A GAMLSS approach of MemTrax in China.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Establishment of Thyroid Volume Reference Curves for Children in Xinjiang: An Exploration of Goiter Diagnosis and the Role of Iodine Nutrition.Biological trace element research · 2026Article
- Beyond traditional assessments of cognitive status: Exploring the potential of spatial navigation tasks.Behavior research methods · 2026Article
- A Global, Regional, and National Survey on Burden and Quality of Care Index of Alzheimer's Disease and Other Dementias in Adults Aged 55 and Above: The Global Burden of Disease Study 1990-2021.Neuroepidemiology · 2026Article
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- Predicting brain amyloid load with digital and blood-based biomarkers.Alzheimer's research & therapy · 2025Article
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- Toward better understanding and management of chemobrain: the potential utilities of the MemTrax memory test.BMC women's health · 2024Article
- Research on the application of functional near-infrared spectroscopy in differentiating subjective cognitive decline and mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Toward digitally screening and profiling AD: A GAMLSS approach of MemTrax in China.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Development of amyloid-negative neuropsychological norms using GAMLSS.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
12 authors.
Funding
Abstract
purposesTo establish a normative range of MemTrax (MTx) metrics in the Chinese population.
methodsThe correct response percentage (MTx-%C) and mean response time (MTx-RT) were obtained and the composite scores (MTx-Cp) calculated. Generalized additive models for location, shape and scale (GAMLSS) were applied to create percentile curves and evaluate goodness of fit, and the speed-accuracy trade-off was investigated.
results26,633 subjects, including 13,771 (51.71%) men participated in this study. Age- and education-specific percentiles of the metrics were generated. Q tests and worm plots indicated adequate fit for models of MTx-RT and MTx-Cp. Models of MTx-%C for the low and intermediate education fit acceptably, but not well enough for a high level of education. A significant speed-accuracy trade-off was observed for MTx-%C from 72 to 94.
conclusionsGAMLSS is a reliable method to generate smoothed age- and education-specific percentile curves of MTx metrics, which may be adopted for mass screening and follow-ups addressing Alzheimer's disease or other cognitive diseases. HIGHLIGHTS: GAMLSS was applied to establish nonlinear percentile curves of cognitive decline. Subjects with a high level of education demonstrate a later onset and slower decline of cognition. Speed-accuracy trade-off effects were observed in a subgroup with moderate accuracy. MemTrax can be used as a mass-screen instrument for active cognition health management advice.
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