ArticleJournal of chemical information and modeling2023
Deciphering the Allosteric Activation Mechanism of SIRT6 Using Molecular Dynamics Simulations.
Zhiyuan Zhao, Jintong Du, Yu Du, Yuan Gao, Mingxuan Yu, Yingkai Zhang, Hao Fang, Xuben Hou
Open access · greenAbstract read
In one paragraphArticle in Journal of chemical information and modeling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 2 countries.
Zhiyuan ZhaoDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Jintong DuDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Yu DuDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Yuan GaoDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Mingxuan YuDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Hao FangDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.ORCID 0000-0002-2879-5146 Xuben HouDepartment of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.ORCID 0000-0002-8346-9001 Shandong University · CNNew York University · US
Funding
Computational modulator design and machine learning to target protein-protein interactionsR35GM127040 · NIGMS · NEW YORK UNIVERSITY · PI Yingkai Zhang · 2018 to 2026
$4.6MNIGMS NIH HHS R35 GM127040
6 · The paper itselfAbstract
As a member of the histone deacetylase protein family, the NAD
Indexed as
Molecular Dynamics SimulationSirtuinsAllosteric RegulationFatty AcidsGlycosyltransferasesNADFatty AcidsGlycosyltransferasesNADSirtuins
Identifiers
PMID37653718
PMCPMC10530556
OpenAlexW4386347481
What OpenQuestion holds
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LicenceTDM
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