Evidence map›Paper›PMID 37653641›Full record

Trial reportJournal of human lactation : official journal of International Lactation Consultant Association2023

Inflammatory Markers in Mother's Own Milk and Infant Stool of Very Low Birthweight Infants.

Rebecca Hoban, Hadar Nir, Emily Somerset, Jordan Lewis, Sharon Unger, Deborah L O'Connor

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of human lactation : official journal of International Lactation Consultant Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02137473 (Optimizing Mothers' Milk for Preterm Infants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02137473 nacompletednot on this map

Optimizing Mothers' Milk for Preterm Infants (OptiMoM) Program of Research: Study 2-Bovine vs. Human Milk-Based Fortifier Study

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2014 to 2016Enrolled127ConditionsVery Low Birth Weight Infant (<1250g)ArmsHuman milk-based fortifier, Bovine protein-based fortifier
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Rebecca HobanDepartment of Paediatrics, Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-9457-8791
Hadar NirDepartment of Paediatrics, Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.
Emily SomersetRogers Computational Program, Ted Rogers Centre for Heart Research, The Hospital for Sick Children, University Health Network, Toronto, ON, Canada.
Jordan LewisDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Sharon UngerDepartment of Paediatrics, Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.
Deborah L O'ConnorDepartment of Nutrition, University of Toronto, Toronto, ON, Canada.
Hospital for Sick Children · CAMount Sinai Hospital · CATel Aviv University · ILUniversity Health Network · CAUniversity of British Columbia · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundMother's breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this vulnerable population. RESEARCH

aimTo assess cytokines and inflammatory markers in milk from parents of very preterm infants over time as well as correlations between milk and infant's stool calprotectin.

methodThis is a secondary analysis of milk samples collected during OptiMoM, a triple-blind randomized clinical trial of infants born < 1250 g (NCT02137473). Longitudinally collected samples were analyzed for cytokines, choline, and inflammatory markers (C-reactive protein [CRP], IFN-γ, IL-10, IL-1β, IL-1ra, IL-6, IL-8, TNF-α). Infant stools were collected for longitudinal calprotectin analysis. Generalized estimating equations quantified longitudinal profiles of milk markers and stool calprotectin, their associations, and the correlation between free choline and C-reactive protein over follow-up.

resultParticipants included 92 parents and infants (median weeks of gestation 27.3, median birth weight 845 g, and prevalence of male infants 45%). In all, 212 milk samples and 94 corresponding stool calprotectin levels were collected 1-11 weeks postpartum. C-reactive protein was present in much higher concentrations than other markers, and was highest in Week 1 postpartum. It decreased over time. IL-8 and free choline also changed over time while other markers did not. There was no correlation between any milk markers and stool calprotectin.

conclusionMilk from mothers of very preterm infants has detectable inflammatory markers, some of which change over time. Research is needed to determine if infant outcomes are associated with these markers.

Indexed as

Infant, PrematureMilk, HumanBreast FeedingCholineC-Reactive ProteinCytokinesFemaleHumansInfantInfant, NewbornInfant, Very Low Birth WeightInterleukin-8Leukocyte L1 Antigen ComplexMaleMothersCholineC-Reactive ProteinCytokinesInterleukin-8Leukocyte L1 Antigen ComplexbreastfeedingC reactive proteincytokineshuman milkinflammationpreterm infantstool calprotectin

Identifiers

PMID37653641
PMCPMC10580668
OpenAlexW4386347981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.