Evidence map›Paper›PMID 37653534›Full record

ArticleActa neuropathologica communications2023

Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype.

Laura Cracco, Gianfranco Puoti, Antonio Cornacchia, Katie Glisic, Seong-Ki Lee, Zerui Wang, Mark L Cohen, Brian S Appleby, Ignazio Cali

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Post-translational modifications in prion diseases.Frontiers in molecular neuroscience · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Laura CraccoDepartment of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.
Gianfranco Puoti *Division of Neurology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Antonio Cornacchia *Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Katie GlisicNational Prion Disease Pathology Surveillance Center, Cleveland, OH, 44106, USA.
Seong-Ki LeeDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Zerui WangDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Mark L CohenDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Brian S ApplebyDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ignazio CaliDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. ixc20@case.edu.ORCID http://orcid.org/0000-0001-5770-3848
Case Western Reserve University · USIndiana University Indianapolis · USUniversity Hospitals Cleveland Medical Center · USUniversity of Campania "Luigi Vanvitelli" · IT

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Jason C Bartz · 2008 to 2026
$36.1M
Neuropathology Core - P GambettiP01AI106705 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI · 2014 to 2018
$7.7M
Structural correlates of prion strain, phenotype and infectivity in human prion dR01NS083687 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI, SUREWICZ, WITOLD K · 2014 to 2018
$2.9M
Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTER00AG068359 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI CALI, IGNAZIO · 2022 to 2023
$498k
Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTEK99AG068359 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI CALI, IGNAZIO · 2020 to 2021
$242k
NIAID NIH HHS P01 AI077774NIAID NIH HHS P01 AI106705NIA NIH HHS K99 AG068359NIA NIH HHS R00 AG068359NINDS NIH HHS R01 NS083687
6 · The paper itself

Abstract

The MV1 and MV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) are linked to the heterozygous methionine (M)/valine (V) polymorphism at codon 129 of the prion protein (PrP) gene. MV2 is phenotypically heterogeneous, whereas MV1, due to its low prevalence, is one of the least well characterized subtypes. In this study, we investigated the biochemical properties of PrP

Indexed as

Creutzfeldt-Jakob SyndromeKuruPrionsGenotypeHumansPlaque, AmyloidPrion ProteinsPrion ProteinsPrionsCodon 129HistotypePrionPrion proteinRT-QuICsCJD

Identifiers

PMID37653534
PMCPMC10469800
OpenAlexW4386331227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.