ArticleBMC public health2023
Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.
Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Exposure to environmental toxicants and obstructive sleep apnea: a cross-sectional study.Future science OA · 2026Article
- The Potential of Microbiota-Modulating Dietary Strategies in Gallstone Prevention: Evidence from 2 Large Population- Based Cohorts.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Metals and metalloids concentrations in adults aged 50 and older from Mexico.Research square · 2025Article
- Association between the dietary inflammatory index and allergic rhinitis results from the National health and nutrition examination survey (2005-2006).Journal of health, population, and nutrition · 2025Article
- Associations between dietary fatty acids and kidney stones.Scientific reports · 2025Article
- The associations of cardiovascular health and all-cause mortality among individuals with depression.Scientific reports · 2025Article
- Association of blood cadmium levels with epigenetic age acceleration in U.S. adults aged > 50 years.Frontiers in public health · 2025Article
- Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005-2018.Frontiers in endocrinology · 2025Article
- Effects of molecular interactions between the exposome and oxylipin metabolism on healthspan.Frontiers in physiology · 2025Review
- Article
- Association between weight-adjusted waist index and bone mineral density in adolescents.Scientific reports · 2024Article
- Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters.Biomolecules · 2024Review
- Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study.Lipids in health and disease · 2024Article
- Association of cardiovascular health and periodontitis: a population-based study.BMC public health · 2024Article
- Associations between ethylene oxide exposure and chronic bronchitis: results from the NHANES 2013-2018.Frontiers in public health · 2024Article
- Associations between cardiovascular health and female infertility: A national population-based study.PloS one · 2024Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionEven though cadmium (Cd) exposure and cellular senescence (telomere length) have been linked in previous studies, composite molecular aging biomarkers are more significant and reliable factors to consider when examining the connection between metal exposure and health outcomes. The purpose of this research was to assess the association between urinary cadmium (U-Cd) and whole-body aging (phenotypic age).
methodsPhenotypic age was calculated from chronological age and 9 molecular biomarkers. Multivariate linear regression models, subgroup analysis, and smoothing curve fitting were used to explore the linear and nonlinear relationship between U-Cd and phenotypic age. Mediation analysis was performed to explore the mediating effect of U-Cd on the association between smoking and phenotypic age.
resultsThis study included 10,083 participants with a mean chronological age and a mean phenotypic age of 42.24 years and 42.34 years, respectively. In the fully adjusted model, there was a positive relationship between U-Cd and phenotypic age [2.13 years per 1 ng/g U-Cd, (1.67, 2.58)]. This association differed by sex, age, and smoking subgroups (P for interaction < 0.05). U-Cd mediated a positive association between serum cotinine and phenotypic age, mediating a proportion of 23.2%.
conclusionsOur results suggest that high levels of Cd exposure are associated with whole-body aging.
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