Evidence map›Paper›PMID 37653406›Full record

ArticleJournal of nanobiotechnology2023

Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4

Min-Zheng Zhu, Hao-Ming Xu, Yu-Jie Liang, Jing Xu, Ning-Ning Yue, Yuan Zhang, Cheng-Mei Tian, Jun Yao, Li-Sheng Wang, Yu-Qiang Nie and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 3 pooled it
40.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
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  6. Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Min-Zheng Zhu *Department of Gastroenterology and Hepatology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China.
Hao-Ming Xu *Department of Gastroenterology and Hepatology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China.
Yu-Jie Liang *School of Rehabilitation Medicine, Jining Medical University, Jining, 272029, Shandong, China.
Jing Xu *Department of Gastroenterology and Hepatology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China.
Ning-Ning YueDepartment of Gastroenterology, Shenzhen People's Hospital, the Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
Yuan ZhangDepartment of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, 516000, Guangdong, China.
Cheng-Mei TianDepartment of Emergency, Shenzhen People's Hospital, the Second Clinical Medical College, the First Affiliated Hospital, Jinan University, Southern University of Science and Technology, Shenzhen, 518020, Guangdong, China.
Jun YaoDepartment of Gastroenterology, Shenzhen People's Hospital, the Second Clinical Medical College, the First Affiliated Hospital, Jinan University, Southern University of Science and Technology, Shenzhen, 518020, Guangdong, China. yao.jun@szhospital.com.
Li-Sheng WangDepartment of Gastroenterology, Shenzhen People's Hospital, the Second Clinical Medical College, the First Affiliated Hospital, Jinan University, Southern University of Science and Technology, Shenzhen, 518020, Guangdong, China. wanglsszrmyy@163.com.
Yu-Qiang NieDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China. eynieyuqiang@scut.edu.cn.
De-Feng LiDepartment of Gastroenterology, Shenzhen People's Hospital, the Second Clinical Medical College, the First Affiliated Hospital, Jinan University, Southern University of Science and Technology, Shenzhen, 518020, Guangdong, China. ldf830712@163.com.
South China University of Technology · CNJinan University · CNShenzhen Second People's Hospital · CNHuizhou University · CNJining Medical University · CN

Funding

Technical Research and Development Project of Shenzhen No. JCYJ20150403101028164, No. JCYC20170307100911479, No. JCYJ20190807145617113 and JCYJ20210324113802006the Guangdong Basic and Applied Basic Research Foundation No. 2023A1515011936 and No. 2021A1515010985
6 · The paper itself

Abstract

Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof of concept, we isolated and identified Portulaca oleracea L-derived exosome-like nanoparticles (PELNs) from edible Portulaca oleracea L, which exhibited desirable nano-size (~ 160 nm) and a negative zeta potential value (-31.4 mV). Oral administration of PELNs effectively suppressed the expressions of pro-inflammatory cytokines (TNF-α, IL-6, IL-12, and IL-1β) and myeloperoxidase (MPO), increased levels of the anti-inflammatory cytokine (IL-10), and alleviated acute colitis in dextran sulfate sodium (DSS)-induced C57 mice and IL-10

Indexed as

ColitisColitis, UlcerativeExosomesNanoparticlesPortulacaAnimalsCD8-Positive T-LymphocytesCytokinesDNA-Binding ProteinsHydrocarbonsInterleukin-10MiceTranscription FactorsCytokinesDNA-Binding ProteinsHydrocarbonsInterleukin-10Transcription FactorsZbtb7b protein, mouseDouble-positive CD4+CD8+TLactobacillus reuteriPortulaca oleracea L-derived exosome-like nanoparticlesUlcerative colitis

Identifiers

PMID37653406
PMCPMC10469825
OpenAlexW4386329449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.