Evidence map›Paper›PMID 37653346›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2023

Estimating the economic burden of osteoporotic fractures in a multinational study: a real-world data perspective.

A Moayyeri, J Warden, S Han, H S Suh, R Pinedo-Villanueva, N C Harvey, J R Curtis, S Silverman, J K Multani, E J Yeh

Open access · hybridAbstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Burden of accumulating fragility fractures on health service usage and costs among post-menopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  5. Article
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  9. The Role of Copper Intake in Bone Health: A Quantitative Analysis in Postmenopausal Spanish Women.European journal of investigation in health, psychology and education · 2025
    Article
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  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. A 70% EthanolMolecules (Basel, Switzerland) · 2024
    Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

A MoayyeriUCB Pharma, Slough, UK.
J WardenUCB Pharma, Slough, UK.
S HanHealth Outcomes Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.
H S SuhCollege of Pharmacy, Kyung Hee University, Seoul, South Korea.
R Pinedo-VillanuevaNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, NIHR Oxford Biomedical Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7HE, UK.
N C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital, Southampton, UK.
J R CurtisDivision of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
S SilvermanCedars-Sinai Medical Center and School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
J K MultaniIQVIA, Falls Church, VA, USA.
E J YehAmgen Inc., Thousand Oaks, CA, USA. eyeh01@amgen.com.ORCID http://orcid.org/0000-0002-9357-9626
UCB Pharma (United Kingdom) · GBAmgen (United States) · USCedars-Sinai Medical Center · USIQVIA (United States) · USKyung Hee University · KRSouthampton General Hospital · GBThe University of Texas at Austin · USUniversity of Alabama at Birmingham · USUniversity of Oxford · GB

Funding

Medical Research Council MC_PC_21003
6 · The paper itself

Abstract

Fracture-related costs vary by country. A standardized methodology and presentations were proposed to fairly assess the economic burden of osteoporotic fracture. Results indicated substantial costs of osteoporotic fractures for pharmacy, hospitalization, emergency care, and outpatient visits in women aged ≥ 50 years in Australia, Germany, South Korea, Spain, and the USA. PURPOSE: The objective of this multinational, retrospective matched cohort study was to use a standardized methodology across different healthcare systems to estimate the burden of osteoporotic fracture (OF) in women aged ≥ 50 years in Australia, Germany, South Korea, Spain, and the USA.

methodsWithin each country, healthcare resource utilization and direct costs of care were compared between patients with newly identified OF and a propensity score-matched cohort without OF during follow-up periods of up to 5 years.

resultsAcross all five countries, the OF cohort had significantly higher rates and length of inpatient admissions compared with the non-OF cohort. In each country, the adjusted total costs of care ratio between OF and non-OF cohorts were significant. The adjusted cost ratios for pharmacy, inpatient care, emergency care, and outpatient visits were similarly higher in the OF cohort across countries.

conclusionThe current study demonstrates the substantial economic burden of OF across different countries when compared with matched non-OF patients. The findings would assist stakeholders and policymakers in developing appropriate health policies.

Indexed as

Osteoporotic FracturesCohort StudiesCost of IllnessFemaleFinancial StressHealth Care CostsHumansRetrospective StudiesFracturesHealthcare resource utilizationOsteoporosisReal-world evidenceResearch methods

Identifiers

PMID37653346
PMCPMC10651531
OpenAlexW4386317703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.