Evidence map›Paper›PMID 37653266›Full record

ArticleFunctional & integrative genomics2023

Draft genome sequence of Staphylococcus aureus sequence type 5 SA01 isolated from bloodstream infection and comparative analysis with reference strains.

Romulo Maia Ferreira, Douglas Henrique Dos Santos Silva, Karinny Farias Silva, Joveliane de Melo Monteiro, Gabriella Freitas Ferreira, Maria Raimunda Chagas Silva, Luís Claudio Nascimento da Silva, Letícia de Castro Oliveira, Andrea Souza Monteiro

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In one paragraph

Article in Functional & integrative genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Romulo Maia FerreiraLaboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís, 65075-120, MA, Brasil.
Douglas Henrique Dos Santos SilvaLaboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís, 65075-120, MA, Brasil.
Karinny Farias SilvaLaboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís, 65075-120, MA, Brasil.
Joveliane de Melo MonteiroLaboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís, 65075-120, MA, Brasil.
Gabriella Freitas FerreiraDepartamento de Farmácia, Universidade Federal de Juiz de Fora - Campus Governador Valadares, CEP 35010-180, Juiz de Fora, MG, Brasil.
Maria Raimunda Chagas SilvaLaboratório de Ciências Do Ambiente, Universidade CEUMA, São Luís, 65075-120, MA, Brasil.
Luís Claudio Nascimento da SilvaLaboratório de Patogenicidade Microbiana, Universidade CEUMA, São Luís, 65075-120, MA, Brasil. luiscn.silva@ceuma.br.
Letícia de Castro OliveiraDepartamento de Microbiologia, Universidade Federal Do Triângulo Mineiro, Imunologia E Parasitologia, 38025180, Uberaba, MG, Brasil.
Andrea Souza MonteiroLaboratório de Microbiologia Aplicada, Universidade CEUMA, São Luís, 65075-120, MA, Brasil.
Universidade Ceuma · BRUniversidade Federal de Juiz de Fora · BRUniversidade Federal do Triângulo Mineiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A Staphylococcus aureus isolate (SA01) obtained from bloodstream infection exhibited a remarkable drug resistance profile. In this study, we report the draft genome sequence of S. aureus ST 5 SA01, a multidrug-resistant isolate, and analyzed the genes associated with drug resistance and virulence. The genome sketch of S. aureus ST5 SA01 was sequenced with Illumina and annotated using the Prokka software. Rapid Annotation Subsystem Technology (RAST) was used to verify the gene functions in the genome subsystems. The Comprehensive Antibiotic Resistance Database (CARD) and Virulence Factor Database (VFDB) were used in the analysis. The RAST indicated a contribution of 25 proteins to host adenine, fibronectin-binding protein A (FnbA), and biofilm formation as an intercellular polysaccharide adhesive system (PIA). The MLST indicated that S. aureus ST 5 SA01 belongs to ST5 (CC5). In silico analyses also showed an extensive repertoire of genes associated with toxins, such as LukGH leukocidin, enterotoxins, and superantigen staphylococcal classes (SSL). The 11 genes for antimicrobial resistance in S. aureus ST 5 SA01 showed similarity and identity above ≥ 99% with nucleotide sequences deposited in GenBank. Although studies on ST5 clones in Brazil are scarce, monitoring the clone of S. aureus ST 5 SA01 is essential, as it has become a problem in pediatrics in several countries.

Indexed as

SepsisStaphylococcus aureusChildHumansMultilocus Sequence TypingSoftwareAntibiotic resistanceGenomeStaphylococcus aureusVirulence

Identifiers

PMID37653266
OpenAlexW4386316612

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.