ArticleNature biotechnology2024
Imaging brain tissue architecture across millimeter to nanometer scales.
Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mapping brain-wide monosynaptic inputs to single neurons with ROInet-seq.Cell reports methods · 2026Article
- Enhancing biomedical optical volumetric imaging via self-supervised orthogonal learning.Science advances · 2026Article
- Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.Nature communications · 2026Article
- High-resolution, multidimensional solar radiation evaluation for the scientific protection of built heritage sites.Communications engineering · 2026Article
- Universal consensus 3D segmentation of cells from 2D segmented stacks.Nature methods · 2025Article
- Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context.bioRxiv : the preprint server for biology · 2025Article
- In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super-Resolution Imaging and Genome Modification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- VSOT: volume-surface optimization for accurate ultrastructure analysis of dendritic spines.Bioinformatics (Oxford, England) · 2025Article
- Data-driven synapse classification reveals a logic of glutamate receptor diversity.bioRxiv : the preprint server for biology · 2025Article
- Brain imaging turned inside out.Nature biotechnology · 2024Article
- A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution.Science (New York, N.Y.) · 2024Article
- Fluorescence microscopy shadow imaging for neuroscience.Frontiers in cellular neuroscience · 2024Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease.
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Registered trials
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