Evidence map›Paper›PMID 37653209›Full record

ArticleJournal of general internal medicine2024

Examining Adult Patients' Success with Discontinuing Long-term Benzodiazepine Use: a Qualitative Study.

Linda Takamine, Sarah L Krein, Erika Ratliff, Julie Strominger, Amarra Virk, Donovan T Maust

Open access · bronzeAbstract read
In one paragraph

Article in Journal of general internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Linda TakamineVA Center for Clinical Management Research, VA Ann Arbor Healthcare System, 2215 Fuller Road, Mail Stop 152, Ann Arbor, MI, USA. linda.takamine@va.gov.ORCID 0000-0002-7039-3618
Sarah L KreinVA Center for Clinical Management Research, VA Ann Arbor Healthcare System, 2215 Fuller Road, Mail Stop 152, Ann Arbor, MI, USA.
Erika RatliffDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Julie StromingerVA Center for Clinical Management Research, VA Ann Arbor Healthcare System, 2215 Fuller Road, Mail Stop 152, Ann Arbor, MI, USA.
Amarra VirkDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.
Donovan T MaustVA Center for Clinical Management Research, VA Ann Arbor Healthcare System, 2215 Fuller Road, Mail Stop 152, Ann Arbor, MI, USA.
University of Michigan · USVA Ann Arbor Healthcare System · USUniversity of South Florida · US

Funding

Addressing inappropriate benzodiazepine prescribing among older VeteransI01HX002340 · VA · VETERANS HEALTH ADMINISTRATION · PI MAUST, DONOVAN T · 2018 to 2022
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Research Career Scientist AwardIK6HX003399 · VA · VETERANS HEALTH ADMINISTRATION · PI KREIN, SARAH · 2023 to 2025
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HSRD VA I01 HX002340HSRD VA IK6 HX003399
6 · The paper itself

Abstract

backgroundLittle is known about patients' experiences with benzodiazepine (BZD) discontinuation, which is thought to be challenging given the physiological and psychological dependence and accompanying potential for significant withdrawal symptoms. The marked decline in BZD prescribing over the past decade in the US Department of Veterans Affairs healthcare system presents an important opportunity to examine the experience of BZD discontinuation among long-term users.

objectiveExamine the experience of BZD discontinuation among individuals prescribed long-term BZD treatment to identify factors that contributed to successful discontinuation.

designDescriptive qualitative analysis of semi-structured interviews conducted between April and December of 2020.

participantsA total of 21 Veterans who had been prescribed long-term BZD pharmacotherapy (i.e., > 120 days of exposure in a 12-month period) and had their BZD discontinued. APPROACH: We conducted semi-structured interviews with Veteran participants to learn about their BZD use and the process of discontinuation, with interviews recorded and transcribed verbatim. Data were deductively and inductively coded and coded text entered into a matrix to identify factors that contributed to successful BZD discontinuation. KEY

resultsThe mean age of interview participants was 63.0 years (standard deviation 3.9); 94.2% were male and 76.2% were white. Of 21 participants, only 1 had resumed BZD treatment (prescribed by a non-VA clinician). Three main factors influenced success with discontinuation: (1) participants' attitudes toward BZDs (e.g., risks of long-term use, perceived lack of efficacy, potential for dependence); (2) limited withdrawal symptoms; and (3) effective alternatives, either from their clinician (e.g., medication, psychotherapy) or identified by participants.

conclusionsBZD discontinuation after long-term use is relatively well tolerated, and participants appreciated reducing their medication exposure, particularly to one associated with physical dependence. These findings may help reduce both patient and clinician anxiety related to BZD discontinuation.

Indexed as

Anti-Anxiety AgentsSubstance-Related DisordersSubstance Withdrawal SyndromeAdultAnxiety DisordersBenzodiazepinesFemaleHumansMaleMiddle AgedAnti-Anxiety AgentsBenzodiazepinesbenzodiazepinediscontinuationqualitative

Identifiers

PMID37653209
PMCPMC10853089
OpenAlexW4386347225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.