ArticleNature neuroscience2023
Prominent in vivo influence of single interneurons in the developing barrel cortex.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Decoding Brain Development and Function Through GABAergic Inhibitory Neurons.The European journal of neuroscience · 2026Review
- When inhibition organizes the brain.Nature reviews. Neuroscience · 2026Article
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Article
- Establishing mouse forebrain organoids as models of intrinsic cortical network assembly.Stem cell reports · 2026Article
- Principles of cortical interactions in modular recurrent networks.bioRxiv : the preprint server for biology · 2026Article
- Patterned wireless transcranial optogenetics generates artificial perception.Nature neuroscience · 2026Article
- Cognitive impairment after cerebral ischemia-reperfusion injury: a neuroecosystem perspective.Frontiers in neurology · 2026Review
- Article
- Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p.eLife · 2025Article
- Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex.Nature communications · 2025Article
- Subtype- and Layer-Specific Developmental Gradients of Postnatal GABAergic Neurons in the Rodent Barrel Cortex.Developmental neuroscience · 2025Article
- Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities.Neurobiology of stress · 2025Article
- From initial formation to developmental refinement: GABAergic inputs shape neuronal subnetworks in the primary somatosensory cortex.iScience · 2025Article
- GABAergic integration of transient and persistent neurons in the developing mouse somatosensory cortex.Frontiers in cellular neuroscience · 2025Article
- Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus.PLoS biology · 2024Article
- Restoring transient connectivity during development improves dysfunctions in fragile X mice.bioRxiv : the preprint server for biology · 2024Article
- Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development.Neuron · 2024Article
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Dynamics of mature myelin.Nature neuroscience · 2024Review
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous synchronous activity is a hallmark of developing brain circuits and promotes their formation. Ex vivo, synchronous activity was shown to be orchestrated by a sparse population of highly connected GABAergic 'hub' neurons. The recent development of all-optical methods to record and manipulate neuronal activity in vivo now offers the unprecedented opportunity to probe the existence and function of hub cells in vivo. Using calcium imaging, connectivity analysis and holographic optical stimulation, we show that single GABAergic, but not glutamatergic, neurons influence population dynamics in the barrel cortex of non-anaesthetized mouse pups. Single GABAergic cells mainly exert an inhibitory influence on both spontaneous and sensory-evoked population bursts. Their network influence scales with their functional connectivity, with highly connected hub neurons displaying the strongest impact. We propose that hub neurons function in tailoring intrinsic cortical dynamics to external sensory inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.