Evidence map›Paper›PMID 37652906›Full record

ArticleNPJ Parkinson's disease2023

Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.

Alejandro Martinez-Carrasco, Raquel Real, Michael Lawton, Hirotaka Iwaki, Manuela M X Tan, Lesley Wu, Nigel M Williams, Camille Carroll, Michele T M Hu, Donald G Grosset and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Does COMT Play a Role in Parkinson's Disease Susceptibility across Diverse Ancestral Populations?Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  5. Review
  6. Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  7. Parkinson's Disease is Predominantly a Genetic Disease.Journal of Parkinson's disease · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 5 countries.

Alejandro Martinez-CarrascoDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK. alejandro.carrasco.20@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6191-1703
Raquel RealDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-8117-742X
Michael LawtonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-3419-0354
Hirotaka IwakiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Manuela M X TanDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-5835-669X
Lesley WuDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Nigel M WilliamsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-1177-6931
Camille CarrollFaculty of Health, University of Plymouth, Plymouth, UK.
Michele T M HuNuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UK.
Donald G GrossetSchool of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
John HardyAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Mina RytenAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID http://orcid.org/0000-0001-9520-6957
Tom FoltynieDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0003-0752-1813
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Maryam ShoaiAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Huw R MorrisDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK. h.morris@ucl.ac.uk.ORCID http://orcid.org/0000-0002-5473-3774
National Hospital for Neurology and Neurosurgery · GBUniversity of Bristol · GBCardiff University · GBEnergy Institute · GBGreat Ormond Street Hospital · GBHong Kong University of Science and Technology · HKNational Institutes of Health · USNewcastle University · GBOslo University Hospital · NOQueen Mary University of London · GBUK Dementia Research Institute · GBUniversity of Glasgow · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

The genetic basis of levodopa-induced-dyskinesia (LiD) is poorly understood, and there have been few well-powered genome-wide studies. We performed a genome-wide survival meta-analyses to study the effect of genetic variation on the development of LiD in five separate longitudinal cohorts, and meta-analysed the results. We included 2784 PD patients, of whom 14.6% developed LiD. We found female sex (HR = 1.35, SE = 0.11, P = 0.007) and younger age at onset (HR = 1.8, SE = 0.14, P = 2 × 10

Identifiers

PMID37652906
PMCPMC10471743
OpenAlexW4386316574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.