Evidence map›Paper›PMID 37652704›Full record

ArticleNeurology2023

Plasma Biomarker Profile and Clinical Correlations in Adult Patients With Tuberous Sclerosis Complex.

Biagio Orlando, Alessandra Morano, Valeria Manzini, Emanuele Cerulli Irelli, Maria S Borioni, Caterina Veroni, Enrico Michele Salamone, Chiara D'Amelio, Elisa Moliterni, Sandra Giustini and 6 more

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In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.5field-weighted citation impact, top 34% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

Serum NfL, GFAP, and p-tau217 in adults with drug-resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury.Epilepsia · 2026
Article
Distinct peripheral pro-inflammatory profile associated with tuberous sclerosis complex and epilepsy.Epilepsia · 2025
Article
Circulating biomarkers of kidney angiomyolipoma and cysts in tuberous sclerosis complex patients.iScience · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Biagio OrlandoFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0009-0003-7019-9334

Alessandra MoranoFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0003-3649-8990

Valeria ManziniFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-2224-3594

Emanuele Cerulli IrelliFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).

Maria S BorioniFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0009-0002-5450-483X

Caterina VeroniFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-6043-1051

Enrico Michele SalamoneFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-9619-7455

Chiara D'AmelioFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0009-0003-8936-6032

Elisa MoliterniFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0003-2010-3958

Sandra GiustiniFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0001-7034-3816

Gabriele RuffoloFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-6554-5496

Ivan ArisiFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-0536-2508

Mara D'OnofrioFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-5199-7918

Anna T GiallonardoFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0003-3315-6071

Paola PiscopoFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.).ORCID https://orcid.org/0000-0002-0693-4969

Carlo Di BonaventuraFrom the Department of Human Neurosciences (B.O., A.M., E.C.I., M.S.B., E.M.S., A.T.G., C.D.B.), "Sapienza" University of Rome; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini (V.M., C.D.A., I.A., M.D.O.) Department of Neurosciences (C.V., P.P.), Istituto Superiore di Sanità, Rome; Department of Odontostomatological and Maxillofacial Sciences (E.M.), "Sapienza" University of Rome; Department of Clinical Internal (S.G.), Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome; Department of Physiology and Pharmacology (G.R.), Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Italy; and Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) San Raffaele Roma (G.R.). c_dibonaventura@yahoo.it.

European Brain Research Institute · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDifferent pathophysiologic mechanisms, especially involving astrocytes, could contribute to tuberous sclerosis complex (TSC). We assessed neurodegeneration and astrocytopathy plasma biomarkers in adult patients with TSC to define TSC biomarker profile and investigate clinical-radiologic correlations.

methodsPatients with TSC aged 15 years or older followed at Policlinico "Umberto I" of Rome were consecutively enrolled (July 2021-June 2022). The plasma levels of the following biomarkers were compared between patients and age/sex-matched healthy controls (HCs): tTau, pTau181, Abeta

resultsThirty-one patients (20 females/11 males; median age 30 years, interquartile range 24-47) and 38 HCs were enrolled. Only GFAP was significantly higher in the whole TSC population than in HCs (132.71 [86.14-231.06] vs 44.80 [32.87-66.76] pg/mL, DISCUSSION: Our exploratory study documented a significant increase of GFAP plasma concentration in adult patients with TSC, correlated with their neurologic severity, supporting the central role of astrocytopathy in TSC pathophysiology.

Indexed as

Autism Spectrum DisorderTuberous SclerosisAdultAstrocytesBiomarkersFemaleGenotypeGlial Fibrillary Acidic ProteinHumansMaleBiomarkersGlial Fibrillary Acidic Protein

Identifiers

PMID37652704

DOI10.1212/WNL.0000000000207799

PMCPMC10663002

OpenAlexW4386317991

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