ArticleNeurology2023
Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery.
Open access · greenAbstract read
In one paragraph
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pooled it
- Learning From Our Failures: When Anterior Temporal Lobectomies Fail.Epilepsy currents · 2026Article
- Structural and effective brain connectivity in focal epilepsy.Neuroimage. Reports · 2025Article
- Geometric representations of brain networks can predict the surgery outcome in temporal lobe epilepsy.NPJ systems biology and applications · 2025Article
- Eigenvector biomarker for prediction of epileptogenic zones and surgical success from interictal data.Frontiers in network physiology · 2025Article
- Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection-hub alignment in interictal intracranial EEG networks.Epilepsia · 2024Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- A spatial perturbation framework to validate implantation of the epileptogenic zone.Nature communications · 2024Article
- Neddylation of protein, a new strategy of protein post-translational modification for targeted treatment of central nervous system diseases.Frontiers in neuroscience · 2024Review
- Network coupling and surgical treatment response in temporal lobe epilepsy: A proof-of-concept study.Epilepsy & behavior : E&B · 2023Article
- Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.Frontiers in network physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 4 countries.
Nishant SinhaFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada. nishant.sinha@pennmedicine.upenn.edu peter.taylor@newcastle.ac.uk.ORCID 0000-0002-2090-4889
John S DuncanFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.
Beate DiehlFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.ORCID 0000-0002-6896-854X
Fahmida A ChowdhuryFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.
Jane de TisiFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.
Anna MiserocchiFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.
Andrew William McEvoyFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.
Kathryn A DavisFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.ORCID 0000-0002-7020-6480
Sjoerd B VosFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.ORCID 0000-0002-8502-4487
Gavin P WinstonFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.ORCID 0000-0001-9395-1478
Yujiang WangFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.
Peter Neal TaylorFrom the Department of Neurology (N.S., K.A.D.), Penn Epilepsy Center, Perelman School of Medicine, and Center for Neuroengineering and Therapeutics (N.S., K.A.D.), University of Pennsylvania, Philadelphia; Translational and Clinical Research Institute (Y.W., P.N.T.), Faculty of Medical Sciences, and Computational Neuroscience, Neurology, and Psychiatry Lab (Y.W., P.N.T.), ICOS Group, School of Computing, Newcastle University; Department of Epilepsy (J.S.D., B.D., F.A.C., J.d.T., A.M., A.W.M., G.P.W., Y.W., P.N.T.), UCL Queen Square Institute of Neurology; UCL Centre for Medical Image Computing (S.B.V.); Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, London; MRI Unit (J.S.D., G.P.W.), Chalfont Centre for Epilepsy, Bucks, United Kingdom; Centre for Microscopy, Characterisation, and Analysis (S.B.V.), The University of Western Australia, Nedlands; and Division of Neurology (G.P.W.), Department of Medicine, Queen's University, Kingston, Canada.ORCID 0000-0003-2144-9838
The University of Western Australia · AU
Funding
Optimized Intracranial EEG Targeting in Focal Epilepsy based upon Neuroimaging ConnectomicsR01NS116504 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVIS, KATHRYN ADAMIAK · 2021 to 2025
$3.3MDepartment of HealthMedical Research Council G0802012Medical Research Council MR/M00841X/1Medical Research Council MR/T04294X/1NINDS NIH HHS R01 NS116504Wellcome Trust 105617/Z/14/ZWellcome Trust 208940/Z/17/ZWellcome Trust 210109/Z/18/ZWellcome Trust WT 218380
Abstract
BACKGROUND AND
objectivesSurgery is an effective treatment for drug-resistant epilepsy, which modifies the brain's structure and networks to regulate seizure activity. Our objective was to examine the relationship between brain structure and function to determine the extent to which this relationship affects the success of the surgery in controlling seizures. We hypothesized that a stronger association between brain structure and function would lead to improved seizure control after surgery.
methodsWe constructed functional and structural brain networks in patients with drug-resistant focal epilepsy by using presurgery functional data from intracranial EEG (iEEG) recordings, presurgery and postsurgery structural data from T1-weighted MRI, and presurgery diffusion-weighted MRI. We quantified the relationship (coupling) between structural and functional connectivity by using the Spearman rank correlation and analyzed this structure-function coupling at 2 spatial scales: (1) global iEEG network level and (2) individual iEEG electrode contacts using virtual surgeries. We retrospectively predicted postoperative seizure freedom by incorporating the structure-function connectivity coupling metrics and routine clinical variables into a cross-validated predictive model.
resultsWe conducted a retrospective analysis on data from 39 patients who met our inclusion criteria. Brain areas implanted with iEEG electrodes had stronger structure-function coupling in seizure-free patients compared with those with seizure recurrence ( DISCUSSION: Our study showed that the strength of structure-function connectivity coupling may play a crucial role in determining the success of epilepsy surgery. By quantitatively incorporating structure-function coupling measures and standard-of-care clinical variables into presurgical evaluations, we may be able to better localize epileptogenic tissue and select patients for epilepsy surgery. CLASSIFICATION OF EVIDENCE: This is a Class IV retrospective case series showing that structure-function mapping may help determine the outcome from surgical resection for treatment-resistant focal epilepsy.
Indexed as
Drug Resistant EpilepsyEpilepsies, PartialEpilepsyBrainElectrocorticographyElectroencephalographyHumansRetrospective StudiesSeizuresTreatment Outcome
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