Evidence map›Paper›PMID 37652295›Full record

SynthesisChest2024

Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?: A Systematic Review and Meta-Analysis.

Aishwarya Lakshmi Vidyasagaran, Anne Readshaw, Melanie Boeckmann, Alexander Jarde, Faraz Siddiqui, Anna-Marie Marshall, Janita Akram, Jonathan E Golub, Kamran Siddiqi, Omara Dogar

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Chest, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Post-tuberculosis lung disease.Breathe (Sheffield, England) · 2026
    Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aishwarya Lakshmi VidyasagaranDepartment of Health Sciences, University of York, York, England.
Anne ReadshawDepartment of Health Sciences, University of York, York, England; Yorkshire and North Lincolnshire Area Team, Natural England.
Melanie BoeckmannDepartment of Global Health, Institute of Public Health and Nursing Research (IPP), University of Bremen, Bremen, Germany.
Alexander JardeUniversité de Paris, Centre d'Épidémiologie Clinique, Hôpital Hôtel-Dieu, and Cochrane France, Paris, France.
Faraz SiddiquiDepartment of Health Sciences, University of York, York, England.
Anna-Marie MarshallDepartment of Health Sciences, University of York, York, England; Research Fellow in Public Health and lecturer in Public Health and Psychology, Helen McArdle Nursing and Care Research Institute, Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, England.
Janita AkramHull York Medical School, University of York, York, England.
Jonathan E GolubCenter for Tuberculosis Research, School of Medicine, Johns Hopkins University, Baltimore, MD.
Kamran SiddiqiDepartment of Health Sciences, University of York, York, England; Hull York Medical School, University of York, York, England.
Omara DogarDepartment of Health Sciences, University of York, York, England; Usher Institute, The University of Edinburgh, Edinburgh, Scotland. Electronic address: omara.dogar@york.ac.uk.

Funding

Medical Research Council MR/X004228/1
6 · The paper itself

Abstract

backgroundAssociations between tobacco use and poor TB treatment outcomes are well documented. However, for important outcomes such as TB recurrence or relapse and mortality during treatment, as well as for associations with smokeless tobacco (ST), the evidence is not summarized systematically. RESEARCH QUESTION: Is tobacco use associated with risk of poor treatment outcomes among people with TB? STUDY DESIGN AND

methodsThe MEDLINE, Embase, and Cumulative Index of Nursing and Allied Health Literature databases were searched on November 22, 2021. Epidemiologic studies reporting associations between tobacco use and at least one TB treatment outcome were eligible. Independent double-screening, extractions, and quality assessments were undertaken. Random effects meta-analyses were conducted for the two primary review outcomes (TB recurrence or relapse and mortality during treatment), and heterogeneity was explored using subgroups. Other outcomes were synthesized narratively.

resultsOur searches identified 1,249 records, of which 28 were included in the meta-analyses. Based on 15 studies, higher risk of TB recurrence or relapse was found with ever using tobacco vs never using tobacco (risk ratio [RR], 1.78; 95% CI, 1.31-2.43; I

interpretationTobacco use significantly increases the risk of TB recurrence or relapse and mortality during treatment among people with TB, highlighting the need to address tobacco use to improve TB outcomes. TRIAL REGISTRY: PROSPERO; No.: CRD42017060821; URL: https://www.crd.york.ac.uk/prospero/.

Indexed as

Tobacco UseHumansRecurrenceRisk FactorsTreatment Outcomemeta-analysisrisk of mortalityrisk of recurrencesmokingsystematic reviewTBtobacco

Identifiers

PMID37652295
PMCPMC10790178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.