ArticleCell2023
Structural basis for ion selectivity in potassium-selective channelrhodopsins.
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In one paragraph
Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Molecular mechanism of calcium inhibition in viral channelrhodopsins.Nature communications · 2026Article
- Channel gating in bacteriorhodopsin-like channelrhodopsins with contrasting KBiophysical journal · 2026Article
- Experimentally informed, quantitative photocycle model of the light-gated potassium channel WiChR.Biophysical journal · 2026Article
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- Theoretical analysis of low-power optogenetic suppression of action potentials in human ventricular cardiomyocytes expressed with potassium-selective channelrhodopsins.Scientific reports · 2026Article
- Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Article
- Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens.Nature communications · 2025Article
- Pore-Opening and Ion-Conduction Mechanism in Channelrhodopsins C1C2, ChR2, and iChloC by Computational Electrophysiology and Constant-pH Simulations.Journal of chemical information and modeling · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- Optogenetic engineering for ion channel modulation.Current opinion in chemical biology · 2025Review
- The Cation-π Interaction in Chemistry and Biology.Chemical reviews · 2025Review
- Structural insights into light-gating of potassium-selective channelrhodopsin.Nature communications · 2025Article
- Suppression of epileptic seizures by transcranial activation of KNature communications · 2025Article
- Review
- Protonation states of highly conserved carboxylic acids in NeoR.Biophysics and physicobiology · 2025Article
- Review
- Channelrhodopsins with distinct chromophores and binding patterns.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 5 institutions in 3 countries.
Seiya TajimaKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
Yoon Seok KimDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Masahiro FukudaKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
YoungJu JoDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Peter Y WangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Joseph M PaggiDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Masatoshi InoueDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Eamon F X ByrneDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Koichiro E KishiKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
Seiwa NakamuraKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
Charu RamakrishnanCNC Program, Stanford University, Stanford, CA, USA.
Shunki TakaramotoThe Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan.
Takashi NagataThe Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan.
Masae KonnoThe Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan; PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan.
Masahiro SugiuraDepartment of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Japan.
Kota KatayamaDepartment of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Japan.
Toshiki E MatsuiKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
Keitaro YamashitaMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Suhyang KimKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
Hisako IkedaKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan.
Jaeah KimDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Hideki KandoriDepartment of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Japan; OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Japan.
Ron O DrorDepartment of Computer Science, Stanford University, Stanford, CA, USA; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA.
Keiichi InoueThe Institute for Solid State Physics, The University of Tokyo, Kashiwa, Japan.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA, USA; CNC Program, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. Electronic address: deissero@stanford.edu.
Hideaki E KatoKomaba Institute for Science, The University of Tokyo, Meguro, Tokyo, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan; FOREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan. Electronic address: hekato@bio.c.u-tokyo.ac.jp.
The University of Tokyo · JPStanford University · USNagoya Institute of Technology · JPJapan Science and Technology Agency · JPMRC Laboratory of Molecular Biology · GB
Funding
Resource Core 3 - Teaching/Training/Dissemination Core (TTDC)U19NS118284 · NINDS · STANFORD UNIVERSITY · PI LO, MAISIE KY · 2021 to 2025
$18.1MChannel Structure-Based Tools for Precise Interrogation of Circuitry and BehaviorR37MH075957 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2013 to 2022
$7.3MTechnology development for fast optical interrogation of living neural circuitryR01MH075957 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2008 to 2012
$2.6MHoward Hughes Medical InstituteMedical Research Council MC_UP_A025_1012NIMH NIH HHS R01 MH075957NIMH NIH HHS R37 MH075957NINDS NIH HHS U19 NS118284
Abstract
KCR channelrhodopsins (K
Indexed as
ChannelrhodopsinsRhinosporidiumCryoelectron MicroscopyHumansIon ChannelsPotassiumChannelrhodopsinsIon ChannelsPotassiumchannelrhodopsincryo-EMelectrophysiologyHcKCRMD simulationmicrobial opsinoptogeneticspotassium channelspectroscopystructure-guided engineering
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.