ArticleCell host & microbe2023
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization.
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Article in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
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Who cites it
51 citing papers in PubMed, 56 citations in OpenAlex.
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- The Effect of Arginine Supplementation on Intestinal Antioxidant Capacity, Whole Blood Cell Count and Antiviral Immune Function of Piglets Infected with Porcine Epidemic Diarrhea Virus.Animals : an open access journal from MDPI · 2026Article
- Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.Nature communications · 2026Article
- Intermittent Administration of Helminth-Derived Fh15 Modulates Gut Microbiota and Partially Mitigates Dysbiosis in Early Stages of Severe Experimental Colitis.International journal of molecular sciences · 2026Article
- Gut microbiota modulates synaptic plasticity, connectivity, and dopamine transmission in the VTA-mPFC pathway in bipolar depression.Molecular psychiatry · 2026Article
- Resident microbes shape host immunity and protect against pathogen infection and inflammatory disease.Cellular and molecular life sciences : CMLS · 2026Review
- Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity.Current opinion in immunology · 2026Review
- Bridging the Gut Microbiota and the Brain, Kidney, and Cardiovascular Health: The Role of Probiotics.Probiotics and antimicrobial proteins · 2026Review
- Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistantbioRxiv : the preprint server for biology · 2026Article
- The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition.Biochemistry and biophysics reports · 2026Article
- VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation.Nature communications · 2026Article
- Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression.Alimentary pharmacology & therapeutics · 2026Article
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Authors and funding
21 authors at 7 institutions in 1 country.
Kyung Ku JangDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Thomas HeaneyDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Mariya LondonDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Yi DingDepartment of Laboratory Medicine, Geisinger Health, Danville, PA 17822, USA.
Gregory PutzelDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA.
Frank YeungDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Defne ErcelenDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Ying-Han ChenDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Jordan AxelradDivision of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Sakteesh GurunathanDivision of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Chaoting ZhouCell and Molecular Biology Graduate Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Magdalena PodkowikAntimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA; Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Natalia ArguellesDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA.
Anusha SrivastavaDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA.
Bo ShopsinDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA; Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA.
A Marijke Keestra-GounderDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Alejandro PirontiDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA.
Matthew E GriffinDepartment of Immunology and Microbiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Howard C HangDepartment of Immunology and Microbiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ken CadwellDivision of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: ken.cadwell@pennmedicine.upenn.edu.
New York University · USGeisinger Health System · USScripps Institution of Oceanography · USScripps Research Institute · USTranslational Therapeutics (United States) · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Pennsylvania · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MDiabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3MRedefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6MThe role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2MMechanisms of MRSA intestinal colonizationR01AI140754 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO · 2020 to 2024
$3.5MInteractions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3MHost-pathogen interactions during hospital adaptation of MRSAR01AI137336 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO, YANAI, ITAI · 2019 to 2022
$3.3MThe impact of ER stress on Salmonella Typhimurium infectionsR01AI173121 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Arina Marijke Keestra-Gounder · 2022 to 2026
$2.1MMechanisms of fungal involvement during intestinal diseaseR01DK124336 · NIDDK · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2020 to 2023
$1.8MNOD2 promotes coxsackievirus entry and pathogenesisR21AI164154 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEESTRA-GOUNDER, ARINA MARIJKE · 2021 to 2022
$428kThe effects of a wild gut microbiome on mucosal immunity and diseaseF30DK122698 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI YEUNG, FRANK · 2019 to 2021
$152kSandy Recovery Ventana Medical Systems Discovery XTS10OD018338 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHIRIBOGA, LUIS A · 2014 to 2014
$123kNCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL123340NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI130945NIAID NIH HHS R01 AI137336NIAID NIH HHS R01 AI140754NIAID NIH HHS R01 AI173121NIAID NIH HHS R21 AI164154NIDDK NIH HHS F30 DK122698NIDDK NIH HHS F32 DK132908NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK124336NIH HHS S10 OD018338
Abstract
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiota. Patients with inflammatory bowel disease (IBD) experiencing flares displayed heightened levels of secreted REG3 proteins that mediated depletion of Enterococcus faecium (Efm) from the gut microbiota. Efm inoculation of mice ameliorated intestinal inflammation through activation of the innate immune receptor NOD2, which was associated with the bacterial DL-endopeptidase SagA that generates NOD2-stimulating muropeptides. NOD2 activation in myeloid cells induced interleukin-1β (IL-1β) secretion to increase the proportion of IL-22-producing CD4
Indexed as
Anti-Infective AgentsEnterococcus faeciumInflammatory Bowel DiseasesAnimalsImmunity, InnateInflammationLymphocytesMiceAnti-Infective Agentsantimicrobial proteinsenterococciinflammatory bowel diseaseNOD2REG3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.