Evidence map›Paper›PMID 37651373›Full record

ArticlePloS one2023

The effect of tranexamic acid on intraoperative blood loss in patients undergoing brain meningioma resections: Study protocol for a randomized controlled trial.

Haojie Yu, Minying Liu, Xingyue Zhang, Tingting Ma, Jingchao Yang, Yaru Wu, Jie Wang, Muhan Li, Juan Wang, Min Zeng and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05230381 (Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05230381 naunknown statusnot on this map

Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections: Study Protocol of a Randomised Controlled Trial

TypeinterventionalSponsorBeijing Tiantan HospitalRan2022 to 2025Enrolled228ConditionsTranexamic Acid, Intraoperative Blood Loss, MeningiomaArmsContinous infusion, Single infusion, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Haojie YuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Minying LiuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xingyue ZhangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Tingting MaDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jingchao YangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yaru WuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jie WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Muhan LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Juan WangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Min ZengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Liyong ZhangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hailong JinDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaoyuan LiuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shu LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-5625-067X
Yuming PengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTranexamic acid (TXA) has been proven to prevent thrombolysis and reduce bleeding and blood transfusion requirements in various surgical settings. However, the optimal dose of TXA that effectively reduce intraoperative bleeding and blood product infusion in patients undergoing neurosurgical resection of meningioma with a diameter ≥ 5 cm remains unclear.

methodsThis is a single-center, randomized, double-blinded, paralleled-group controlled trial. Patients scheduled to receive elective tumor resection with meningioma diameter ≥ 5 cm will be randomly assigned the high-dose TXA group, the low-dose group, and the placebo. Patients in the high-dose TXA group will be administered with a loading dose of 20 mg/kg TXA followed by continuous infusion TXA at a rate of 5 mg/kg/h. In the low-dose group, patients will receive the same loading dose of TXA followed by a continuous infusion of normal saline. In the control group, patients will receive an identical volume of normal saline. The primary outcome is the estimated intraoperative blood loss calculated using the following formula: collected blood volume in the suction canister (mL)-the volume of flushing (mL) + the volume from the gauze tampon (mL). Secondary outcomes include calculated intraoperative blood loss, intraoperative coagulation function assessed using thromboelastogram (TEG), intraoperative cell salvage use, blood product infusion, and other safety outcomes. DISCUSSION: Preclinical studies suggest that TXA could reduce intraoperative blood loss, yet the optimal dose was controversial. This study is one of the early studies to evaluate the impact of intraoperative different doses infusion of TXA on reducing blood loss in neurological meningioma patients.

trial registrationClinicalTrials.gov, NCT05230381. Registered on February 8, 2022.

Indexed as

Meningeal NeoplasmsMeningiomaTranexamic AcidBlood Loss, SurgicalBrainHumansRandomized Controlled Trials as TopicSaline SolutionSaline SolutionTranexamic Acid

Identifiers

PMID37651373
PMCPMC10470952
OpenAlexW4386323889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.