Evidence map›Paper›PMID 37651309›Full record

ArticleJournal of proteome research2023

Differential Proteome Profiling Analysis under Pesticide Stress by the Use of a Nano-UHPLC-MS/MS Untargeted Proteomic-Based Approach on a 3D-Developed Neurospheroid Model: Identification of Protein Interactions, Prognostic Biomarkers, and Potential Therapeutic Targets in Human IDH Mutant High-Grade Gliomas.

Kaouthar Louati, Amina Maalej, Fatma Kolsi, Rim Kallel, Yassine Gdoura, Mahdi Borni, Leila Sellami Hakim, Rania Zribi, Sirine Choura, Sami Sayadi and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Kaouthar LouatiLaboratory of Pharmacology, Analytics and Galenic Drug Development- LR12ES09, Faculty of Pharmacy, University of Monastir, Road Avicenne, 5000 Monastir, Tunisia.ORCID 0000-0001-5085-4766
Amina MaalejLaboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, 3018 Sfax, Tunisia.
Fatma KolsiDepartment of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Rim KallelLaboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Yassine GdouraDepartment of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Mahdi BorniDepartment of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Leila Sellami HakimLaboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Rania ZribiHigher Institute of Applied Studies to Humanities of Tunis (ISEAHT), University of Tunis, 11 Road of Jebel Lakdhar, 1005 Tunis, Tunisia.
Sirine ChouraLaboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, 3018 Sfax, Tunisia.
Sami SayadiBiotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar.
Mohamed ChamkhaLaboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, 3018 Sfax, Tunisia.
Basma MnifDepartment of Bacteriology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Zouheir KhemakhemLegal Medicine Department, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Tahya Sellami BoudawaraLaboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Mohamed Zaher BoudawaraDepartment of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.
Fathi SaftaLaboratory of Pharmacology, Analytics and Galenic Drug Development- LR12ES09, Faculty of Pharmacy, University of Monastir, Road Avicenne, 5000 Monastir, Tunisia.
University of Sfax · TNCentre of Biotechnology of Sfax · TNUniversity of Monastir · TNHopital Universitaire Habib Bourguiba · TNQatar University · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-grade gliomas represent the most common group of infiltrative primary brain tumors in adults associated with high invasiveness, agressivity, and resistance to therapy, which highlights the need to develop potent drugs with novel mechanisms of action. The aim of this study is to reveal changes in proteome profiles under stressful conditions to identify prognostic biomarkers and altered apoptogenic pathways involved in the anticancer action of human isocitrate dehydrogenase (IDH) mutant high-grade gliomas. Our protocol consists first of a 3D

Indexed as

Brain NeoplasmsGliomaAdultBiomarkersHumansIsocitrate DehydrogenaseMutationPrognosisProteomeProteomicsTandem Mass SpectrometryBiomarkersIsocitrate DehydrogenaseProteome3D neurospheroidsapoptogenic pathwaysbioinformatic analysisgene ontologygrade-IV astrocytomas IDH mutantnanoflow UHPLCneurotoxicityPPI networksproteomicstandem mass spectrometry (MS/MS)

Identifiers

PMID37651309
PMCPMC10629271
OpenAlexW4386324095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.