Evidence map›Paper›PMID 37651060›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2024

Antibacterial and antioxidant activity of gold and silver nanoparticles in dextran-polyacrylamide copolymers.

Anton Tkachenko, Sadin Özdemir, Gülşah Tollu, Nadir Dizge, Kasim Ocakoglu, Volodymyr Prokopiuk, Anatolii Onishchenko, Vasyl Сhumachenko, Pavlo Virych, Vadym Pavlenko and 1 more

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anton TkachenkoResearch Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, 61022, Ukraine. as.tkachenko@knmu.edu.ua.
Sadin ÖzdemirFood Processing Programme, Technical Science Vocational School, Mersin University, 33343, Yenişehir, Mersin, Turkey.
Gülşah TolluLaboratory and Veterinary Health, Technical Science Vocational School, Mersin University, 33343, Yenişehir, Mersin, Turkey.
Nadir DizgeDepartment of Environmental Engineering, Mersin University, 33343, Yenişehir, Mersin, Turkey. nadirdizge@gmail.com.
Kasim OcakogluDepartment of Eng. Fundamental Sciences, Faculty of Engineering, Tarsus University, 33400, Tarsus, Turkey.
Volodymyr ProkopiukResearch Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, 61022, Ukraine.
Anatolii OnishchenkoResearch Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, 61022, Ukraine.
Vasyl СhumachenkoFaculty of Chemistry, Taras Shevchenko University of Kyiv, Kyiv, 01601, Ukraine.
Pavlo VirychFaculty of Chemistry, Taras Shevchenko University of Kyiv, Kyiv, 01601, Ukraine.
Vadym PavlenkoFaculty of Chemistry, Taras Shevchenko University of Kyiv, Kyiv, 01601, Ukraine.
Nataliya KutsevolFaculty of Chemistry, Taras Shevchenko University of Kyiv, Kyiv, 01601, Ukraine.

Funding

National Research Foundation of Ukraine Project 2020.02/0022 "Plasmon hybrid nanosystems "metal-polymer-fluorophore" withthe Ministry of the Education and Science of Ukraine 0122U00181 "Hybrid nanosystems based on "smart" polymers for biotechnology and medicine"
6 · The paper itself

Abstract

Search for new antimicrobial agents is of great significance due to the issue of antimicrobial resistance, which nowadays has become more important than many diseases. The aim of this study was to evaluate the toxicity and biological effects of a dextran-graft-polyacrylamide (D-PAA) polymer-nanocarrier with/without silver or gold nanoparticles (AgNPs/D-PAA and AuNPs/D-PAA, respectively) to analyze their potential to replace or supplement conventional antibiotic therapy. The toxicity of nanocomplexes against eukaryotic cells was assessed on primary dermal fibroblasts using scratch, micronucleus and proliferation assays. DPPH (2,2-diphenyl-1-picrylhydrazylradical) assay was used to evaluate the antioxidant capacity of D-PAA, AgNPs/D-PAA and AuNPs/D-PAA. DNA cleavage, antimicrobial and biofilm inhibition effects of nanocomplexes were investigated. Nanocomplexes were found to be of moderate toxicity against fibroblasts with no genotoxicity observed. AgNPs/D-PAA reduced motility and proliferation at lower concentrations compared with the other studied nanomaterials. AgNPs/D-PAA and AuNPs/D-PAA showed radical scavenging capacities in a dose-dependent manner. The antimicrobial activity of AgNPs/D-PAA against various bacteria was found to be much higher compared to D-PAA and AuNPs/D-PAA, especially against E. hirae, E. faecalis and S. aureus, respectively. D-PAA, AgNPs/D-PAA and AuNPs/D-PAA showed DNA-cleaving and biofilm inhibitory activity, while AgNPs/D-PAA displayed the highest anti-biofilm activity. AgNPs/D-PAA and AuNPs/D-PAA were characterized by good antimicrobial activity. According to the findings of the study, AgNPs/D-PAA and AuNPs/D-PAA can be evaluated as alternatives for the preparation of new antimicrobial agents, the fight against biofilms, sterilization and disinfection processes. Our findings confirm the versatility of nanosystems based on dextran-polyacrylamide polymers and indicate that AgNPs/D-PAA and AuNPs/D-PAA can be evaluated as alternatives for the preparation of novel antimicrobial agents.

Indexed as

Acrylic ResinsMetal NanoparticlesSilverAnti-Bacterial AgentsAntioxidantsDextransGoldPolyacrylamidesPolymersStaphylococcus aureusAcrylic ResinsAnti-Bacterial AgentsAntioxidantsDextransGoldPolyacrylamidesPolymersSilverAntimicrobial activityAntioxidantDNA cleavageGold nanoparticlesSilver nanoparticles

Identifiers

PMID37651060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.