Evidence map›Paper›PMID 37651006›Full record

ArticleEndocrine2024

A role of NR4A2 in Graves' disease: regulation of Th17/Treg.

Shuiying Zhao, Xinyu Wang, Fengjiao Huang, Yingying Zhou, Dongdong Meng, Di Zhao, Jiao Wang, Haohao Zhang, Lina Wu, Ying Zhang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Regulation ofInternational journal of molecular sciences · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Shuiying Zhao *Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Xinyu Wang *Department of Nuclear Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Fengjiao HuangDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Yingying ZhouDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Dongdong MengDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Di ZhaoDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Jiao WangDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Haohao ZhangDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Lina WuDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Ying ZhangDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Lin ZhaoDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Lixia ZhangDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Yi SongDepartment of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Qingzhu WangDepartment of Nuclear Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China. qingzhuwang@zzu.edu.cn.
First Affiliated Hospital of Zhengzhou University · CN

Funding

the National Natural Science Foundation of China 81900715
6 · The paper itself

Abstract

purposeThis study aimed to explore the molecular pathogenesis of Graves' disease (GD).

methodsThe gene expression profile in CD4

resultsIn the CD4

conclusionThese results indicate that the low level of NR4A2 in GD patients may suppress Treg differentiation, but have no influence on Th17 differentiation, leading to the imbalance of Th17/Treg and contributing to the development of GD. Revealing the role of NR4A2 in GD provides a novel insight for the treatment of GD.

Indexed as

Graves DiseaseT-Lymphocytes, RegulatoryCell DifferentiationHumansInterleukin-10Nuclear Receptor Subfamily 4, Group A, Member 2Th17 CellsInterleukin-10NR4A2 protein, humanNuclear Receptor Subfamily 4, Group A, Member 2Graves’ diseaseNR4A2Th17Treg

Identifiers

PMID37651006
OpenAlexW4386305582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.