Evidence map›Paper›PMID 37650923›Full record

SynthesisEuropean journal of clinical pharmacology2023

The beneficial use of nitric oxide during cardiopulmonary bypass on postoperative outcomes in children and adult patients: a systematic review and meta-analysis of 2897 patients.

Mohamed Abouzid, Yara Roshdy, John Magdy Daniel, Fayed Mohamed Rzk, Ali Ahmed Ali Ismeal, Mohamed Hendawy, Mohammad Tanashat, Marwa Elnagar, Nada Daoud, Alaa Ramadan

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06702553 (Effect of Inhaled Nitric Oxide on Major Adverse Events Requiring Intensive Life Support in Adults Undergoing Cardiac Surgery With Cardiopulmonary Bypass), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06702553 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Inhaled Nitric Oxide on Major Adverse Events Requiring Intensive Life Support in Adults Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Phase III, Double-Blind, Multicenter, Randomized Controlled Trial (Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass, the NORISC Trial)

TypeinterventionalSponsorXijing HospitalRan2025 to 2029Enrolled3,650ConditionsNitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass, Adult Patients Undergoing Cardiovascular Surgery With Cardiopulmonary BypassArmsNitric Oxide Gas, Standard Care Arm
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Mohamed AbouzidDepartment of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3 St., 60-806, Poznan, Poland. mmahmoud@ump.edu.pl.
Yara RoshdyFaculty of Medicine, South Valley University, Qena, Egypt.
John Magdy DanielFaculty of Medicine, Menofia University, Menofia, Egypt.
Fayed Mohamed RzkFaculty of Medicine, Menofia University, Menofia, Egypt.
Ali Ahmed Ali IsmealFaculty of Pharmacy, Minia University, Minya, Egypt.
Mohamed HendawyFaculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Mohammad TanashatFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Marwa ElnagarFaculty of Pharmacy, MTI University, Cairo, Egypt.
Nada DaoudFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Alaa RamadanFaculty of Medicine, South Valley University, Qena, Egypt.
Menoufia University · EGSouth Valley University · EGAlexandria University · EGMinia University · EGPoznan University of Medical Sciences · PLUniversity of Tripoli · LYYarmouk University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInvestigate inhaled nitric oxide's influence on mortality rates, mechanical ventilation and cardiopulmonary bypass duration, and length of stay in the intensive care unit and hospital when administered during cardiopulmonary bypass.

methodsFollowing the PRISMA guidelines, we searched four electronic databases (PubMed, EMBASE, Cochrane Library, and Web of Science) up to 4th March 2023. The protocol was registered in the PROSPERO database with ID: CRD42023423007. Using Review Manager software, we reported outcomes as risk ratios (RRs) or mean difference (MD) and confidence intervals (CIs).

resultsThe meta-analysis included a total of 17 studies with 2897 patients. Overall, there were no significant differences in using nitric oxide over control concerning mortality (RR = 1.03, 95% CI 0.73 to 1.45; P = 0.88) or cardiopulmonary bypass duration (MD = -0.14, 95% CI - 0.96 to 0.69; P = 0.74). The intensive care unit days were significantly lower in the nitric oxide group than control (MD = -0.80, 95% CI - 1.31 to -0.29; P = 0.002). Difference results were obtained in terms of the length of stay in the hospital according to sensitivity analysis (without sensitivity [MD = -0.41, 95% CI - 0.79 to -0.02; P = 0.04] vs. with sensitivity [MD = -0.31, 95% CI - 0.69 to 0.07; P = 0.11]. Subgroup analysis shows that, in children, nitric oxide was favored over control in significantly reducing the duration of mechanical ventilation (MD = -4.58, 95% CI - 5.63 to -3.53; P < 0.001).

conclusionUsing inhaled nitric oxide during cardiopulmonary bypass reduces the length of stay in the intensive care unit, and for children, it reduces the duration of mechanical ventilation.

Indexed as

Cardiopulmonary BypassNitric OxideAdultChildHumansIntensive Care UnitsRespiration, ArtificialNitric OxideCardiopulmonary bypassCPBNitric oxide

Identifiers

PMID37650923
PMCPMC10618325
OpenAlexW4386305221

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.