Evidence map›Paper›PMID 37650897›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024

Factors affecting long-term changes of meibomian gland in MGD patients.

Xichen Wan, Yuqing Wu, Zimeng Zhai, Pei Yang, Shuyun Zhou, Han Ye, Yiteng Lu, Feng Zhou, Xujiao Zhou, Jiaxu Hong

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xichen WanDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Yuqing WuDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Zimeng ZhaiDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Pei YangDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Shuyun ZhouDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Han YeDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Yiteng LuDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Feng ZhouInstitutes of Biomedical Sciences of Fudan University, Shanghai, China.
Xujiao ZhouDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China.
Jiaxu HongDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China. jiaxu.hong@fdeent.org.
Eye & ENT Hospital of Fudan University · CNFudan University · CN

Funding

National Natural Science Foundation of China 81970766National Natural Science Foundation of China 82171102Shanghai Key Clinical Research Program SHDC2020CR3052BShanghai Medical Innovation Research Program 22Y21900900
6 · The paper itself

Abstract

purposeTo explore the long-term course of patients with meibomian gland dysfunction (MGD), and to analyse potential factors affecting the recovery of meibomian gland (MG) dropout.

methodsSeventy-nine MGD patients (79 eyes) aged 36.03±15.78 years old who underwent more than one year of follow-up were enrolled in this retrospective study. Corneal fluorescein staining (CFS), tear meniscus height (TMH), noninvasive breakup time (NIBUT), and noncontact meibography at baseline and last visit were collected and analysed. Then an automatic MG analyzer was used to measure the morphological and functional parameters of MGs, including their area ratio (AR), tortuosity index (TI), and signal index (SI). The patients whose AR increased by more than 5% were defined as MG improvement, and AR decreased by more than 5% was MG worsening.

resultsA total of 79 patients (79 eyes) were assessed with at least 1-year of follow-up. More than 1/3 of MGD patients (27 eyes, 34.2%) underwent MG improvement, and 30.4% of MGs became worsened. Age (P=0.002), gender (P<0.001), IPL treatment (P=0.013), the change of CFS (P=0.0015), and the recovery of SI (P=0.035) showed significant differences among different recovery groups. Age(P<0.001), female sex (P=0.003), ΔCFS (P<0.001), AR at baseline (P<0.001) were negative correlation with AR recovery, and the change of SI (P=0.003) and IPL treatment (P=0.003) had a positive correlation with it. Among them, age (P=0.038), the change of CFS (P=0.004), and AR at baseline (P=0.007) were confirmed as negatively correlated factors predicting the long-term change of the MG.

conclusionAlthough the MGD treatment has continued for more than 1 year, only 34.2% of MGD patients were observed to undergo MG improvement. Younger patients and patients with better CFS recovery seem to have more opportunities to improve their MGs.

Indexed as

Dry Eye SyndromesMeibomian Gland DysfunctionAdultFemaleHumansMeibomian GlandsMiddle AgedRetrospective StudiesTearsYoung AdultFactorsLong-term changeMeibomian glandMeibomian gland dysfunction

Identifiers

PMID37650897
OpenAlexW4386305365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.