ArticleeLife2023
Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Mapping the dual functional organization of the substantia nigra.Molecular psychiatry · 2026Article
- The locus coeruleus at the crossroads of inflammation and neurodegeneration in multiple sclerosis.Journal of neuroinflammation · 2026Review
- Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease.Neurobiology of aging · 2026Article
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Cerebellar subregional structural changes across the Alzheimer's disease continuum: a longitudinal analysis of cognitive and behavioural correlates.Brain communications · 2026Article
- Automated Locus Coeruleus segmentation and age-related signal changes across Neuromelanin-sensitive MRI and T1/T2-weighted images.bioRxiv : the preprint server for biology · 2025Article
- Age-Related Increase in Locus Ceruleus Activity and Connectivity with the Prefrontal Cortex during Ambiguity Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Narcissistic and Antisocial Personality Traits Are Both Encoded in the Triple Network: Connectomics Evidence.Psychophysiology · 2025Article
- Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease.Molecular neurodegeneration · 2025Article
- Regenerating Locus Coeruleus-Norepinephrine (LC-NE) Function: A Novel Approach for Neurodegenerative Diseases.Cell proliferation · 2025Review
- Differential brainstem connectivity according to sex and menopausal status in healthy male and female individuals.Biology of sex differences · 2025Article
- Computational memory capacity predicts aging and cognitive decline.Nature communications · 2025Article
- Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.Neurobiology of aging · 2025Article
- Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer's pathology stages.Acta neuropathologica communications · 2025Article
- Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Exploring Brain Size Asymmetry and Its Relationship with Predation Risk Among Chinese Anurans.Biology · 2025Article
- Different association patterns of emotion regulation and heart rate variability in older and younger adults.Brain communications · 2025Article
- Sensory driven neurophysiological mechanisms of concussion: a parsimonious and falsifiable theory.Frontiers in neurology · 2025Article
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Abstract
The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because of its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown that the LC has heterogeneous connections and cellular features, no studies have yet assessed its functional topography in vivo, how this heterogeneity changes over aging, and whether it is associated with cognition and mood. Here, we employ a gradient-based approach to characterize the functional heterogeneity in the organization of the LC over aging using 3T resting-state fMRI in a population-based cohort aged from 18 to 88 years of age (Cambridge Centre for Ageing and Neuroscience cohort, n=618). We show that the LC exhibits a rostro-caudal functional gradient along its longitudinal axis, which was replicated in an independent dataset (Human Connectome Project [HCP] 7T dataset, n=184). Although the main rostro-caudal direction of this gradient was consistent across age groups, its spatial features varied with increasing age, emotional memory, and emotion regulation. More specifically, a loss of rostral-like connectivity, more clustered functional topography, and greater asymmetry between right and left LC gradients was associated with higher age and worse behavioral performance. Furthermore, participants with higher-than-normal Hospital Anxiety and Depression Scale (HADS) ratings exhibited alterations in the gradient as well, which manifested in greater asymmetry. These results provide an in vivo account of how the functional topography of the LC changes over aging, and imply that spatial features of this organization are relevant markers of LC-related behavioral measures and psychopathology.
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