ArticleEMBO reports2023
Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.
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Article in EMBO reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- BRD4: From molecular understanding to therapeutics development.Molecular cell · 2026Review
- Hypoxia Preserves Chromatin Integrity and Delays Cellular Senescence through Epigenetic Regulation.Biomolecules & therapeutics · 2026Review
- Single-cell transcriptome analysis profiles the enlarged subsets of myeloid-biased HSPCs with preleukemic characters in disuse osteoporosis mice.Cell & bioscience · 2025Article
- Molecular basis of cell fate plasticity - insights from the privileged cells.Current opinion in genetics & development · 2025Review
- Cellular senescence in adult pulmonary hypertension: current state and future challenges.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2025Article
- Basic Epigenetic Mechanisms.Sub-cellular biochemistry · 2025Review
- The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression.npj aging · 2024Review
- Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage.Journal of neuroinflammation · 2024Article
- Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies.Aging and disease · 2024Review
- Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.EMBO reports · 2023Article
- Hematopoiesis: a BETter understanding.EMBO reports · 2023Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Hui Yang *Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Pinpin Sui *Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0003-3779-9592
Ying Guo *Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Shi ChenDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Marie E MaloofSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0001-9320-5918
Guo GeDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-6362-772X
Francine NihozekoDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0003-3078-8612
Caroline R DelmaDepartment of Pathology and Laboratory Medicine, Division of Hematopathology, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0003-0868-7444
Ganqian ZhuDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Peng ZhangDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-3394-6922
Zhenqing YeDepartment of Population Health Sciences, University of Texas Health San Antonio, San Antonio, TX, USA.
Edward A MedinaDepartment of Pathology and Laboratory Medicine, Division of Hematopathology, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-1305-4046
Nagi G AyadDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Ruben MesaMays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA.
Stephen D NimerSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Cheng-Ming ChiangSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4968-3282
Mingjiang XuDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Yidong ChenDepartment of Population Health Sciences, University of Texas Health San Antonio, San Antonio, TX, USA.
Feng-Chun YangDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0001-8524-4095
The University of Texas Health Science Center at San Antonio · USUniversity of Miami · USGeorgetown University · USThe University of Texas Southwestern Medical Center · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1MTumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1MRole of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01CA172408 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2024
$3.4MOpposing Functions of BRD4 Isoforms in Breast CancerR01CA251698 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHIANG, CHENG-MING · 2020 to 2024
$2.3MRoles of TET2-dependent DNA demethylation intermediates in hematological malignanciesR01HL145883 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2019 to 2022
$2.2MEpigenetic pathways and cell cycle exitR01NS118023 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AYAD, NAGI G · 2020 to 2024
$1.8MRole of BRD4 in Normal Hematopoiesis and Hematopoietic Stem Cell Biology_R01HL158081 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI YANG, FENG-CHUN · 2022 to 2024
$1.1MRole of PHF6 in Normal Hematopoiesis and hematopoietic stem cell biologyR01HL149318 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI YANG, FENG-CHUN · 2019 to 2021
$925kHigh Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600kNCI NIH HHS P30 CA054174NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA172408NCI NIH HHS R01 CA251698NHLBI NIH HHS R01 HL145883NHLBI NIH HHS R01 HL149318NHLBI NIH HHS R01 HL158081NIH HHS S10 OD021805NINDS NIH HHS R01 NS118023
Abstract
Bromodomain-containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 in normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse model, we find that deletion of Brd4 (Brd4
Indexed as
HistonesTranscription FactorsAnimalsCell DifferentiationCellular SenescenceHematopoiesisHematopoietic Stem CellsMiceNuclear ProteinsHistonesNuclear ProteinsTranscription FactorsBrd4hematopoiesishistone clippingsenescence
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.