Evidence map›Paper›PMID 37650557›Full record

ArticleAging2023

ZBTB34 is a hepatocellular carcinoma-associated protein with a monopartite nuclear localization signal.

Zheng Liu, Di Jin, Xinran Wei, Yue Gao, Xiaodie Gao, Xia Li, Xiujuan Wang, Pingying Wei, Tao Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zheng LiuCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Di JinCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Xinran WeiCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Yue GaoCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Xiaodie GaoCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Xia LiClinical Laboratory, Hospital Affiliated to Guilin Medical University, Guilin 541001, Guangxi, China.
Xiujuan WangCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Pingying WeiCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, Guangxi, China.
Tao LiuGuihang Guiyang Hospital Affiliated to Zunyi Medical University, Guiyang 550027, Guizhou, China.
Guilin Medical University · CNGuiyang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ZBTB34 is a novel zinc finger protein with an unknown function. In this study, the gene expression and survival prognosis of ZBTB34 were analyzed across tumors based on the TCGA datasets. According to the bioinformatics analysis and qPCR results, liver hepatocellular carcinomas exhibit a high level of ZBTB34 expression. Additionally, the experiment supported the bioinformatics analysis findings that ZBTB34 expression was regulated by miR-125b-5p and that ZBTB34 affected ZBTB10, POLR1B, and AUH expression in HepG2 cells. Biological software analysis further revealed that ZBTB34 contains a monopartite nuclear localization signal (NLS). Arginine and lysine inside the putative NLS were substituted using the alanine-scanning mutagenesis method. The findings showed that the ability of ZBTB34 to enter the nucleus was abolished by the alanine substitution of the sequence

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMicroRNAsAlanineHumansKaryopherinsLysineNuclear Localization SignalsAlanineKaryopherinsLysineMicroRNAsNuclear Localization Signalshepatocellular carcinomaimportin αnuclear localization signalZBTB34

Identifiers

PMID37650557
PMCPMC10496988
OpenAlexW4386304106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.