Evidence map›Paper›PMID 37650378›Full record

ArticleeLife2023

The kleisin subunit controls the function of

Maikel Castellano-Pozo, Georgios Sioutas, Consuelo Barroso, Josh P Prince, Pablo Lopez-Jimenez, Joseph Davy, Angel-Luis Jaso-Tamame, Oliver Crawley, Nan Shao, Jesus Page and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Programmed meiotic errors facilitate dichotomous sperm production in the silkworm,Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Active maintenance of meiosis-specific chromosome structures inbioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Maikel Castellano-PozoMRC London Institute of Medical Sciences, London, United Kingdom.ORCID 0000-0003-4134-9025
Georgios SioutasMRC London Institute of Medical Sciences, London, United Kingdom.
Consuelo BarrosoMRC London Institute of Medical Sciences, London, United Kingdom.
Josh P PrinceMRC London Institute of Medical Sciences, London, United Kingdom.ORCID 0000-0003-0877-7538
Pablo Lopez-JimenezUniversidad Autónoma de Madrid, Madrid, Spain.ORCID 0000-0002-6673-5996
Joseph DavyMRC London Institute of Medical Sciences, London, United Kingdom.
Angel-Luis Jaso-TamameMRC London Institute of Medical Sciences, London, United Kingdom.
Oliver CrawleyMRC London Institute of Medical Sciences, London, United Kingdom.
Nan ShaoMRC London Institute of Medical Sciences, London, United Kingdom.
Jesus PageUniversidad Autónoma de Madrid, Madrid, Spain.ORCID 0000-0001-8381-324X
Enrique Martinez-PerezMRC London Institute of Medical Sciences, London, United Kingdom.ORCID 0000-0001-5813-0383
MRC London Institute of Medical Sciences · GBUniversidad Autónoma de Madrid · ESImperial Valley College · US

Funding

Medical Research Council MC-A652-5PY60Medical Research Council MC_U120097113
6 · The paper itself

Abstract

The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology. In higher eukaryotes, meiotic chromosome function, and therefore fertility, requires cohesin complexes containing meiosis-specific kleisin subunits: REC8 and RAD21L in mammals and REC-8 and COH-3/4 in

Indexed as

Caenorhabditis elegansChromosomal Proteins, Non-HistoneChromosome SegregationAnimalsCaenorhabditis elegans ProteinsCell Cycle ProteinsChromatidsCohesinsIntercellular Signaling Peptides and ProteinsNuclear ProteinsCaenorhabditis elegans ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsIntercellular Signaling Peptides and ProteinsNuclear ProteinsPQN-85 protein, C eleganswapl-1 protein, C elegansC. eleganscell biologychromosomescohesingene expressionmeiosisSCC-2sister chromatid cohesionWAPL

Identifiers

PMID37650378
PMCPMC10497282
OpenAlexW4386305538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.