Evidence map›Paper›PMID 37650337›Full record

ArticleEuropean journal of neurology2024

Clinical evidence in ischemic stroke: Where we have gone so far and hopes for the future.

Tianhua Li, Chengyu Song, David S Liebeskind, Adam A Dmytriw, Ran Xu, Xue Wang, Jie Wang, Hengxiao Zhao, Wenbo Cao, Haozhi Gong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tianhua LiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chengyu SongDepartment of Science and Technology, Medical Library, Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
David S LiebeskindDepartment of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ran XuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xue WangMedical Library, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jie WangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hengxiao ZhaoDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wenbo CaoDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Haozhi GongDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chao ZhangEscope Innovation Academy, Beijing, China.
Xuesong BaiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Liqun JiaoDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-4982-6295

Funding

Beijing Hospitals Authority's Ascent Plan DFL20220702Research and translation application of clinical diagnosis and treatment technology of the capital Z201100005520019Research and translation application of clinical diagnosis and treatment technology of the capital Z201100005520020
6 · The paper itself

Abstract

objectiveIschemic stroke is a significant cause of disability and death worldwide. Randomized clinical trials (RCTs) are important in changing guidelines and treatment strategies. This study aimed to analyze the progress of RCTs in ischemic stroke and to guide future research directions.

methodsIschemic stroke-related RCT articles were identified in six high-impact medical journals using the Web of Science Core Collection database. Google Scholar was used to check whether relevant articles were included in the guidelines. The characteristics of these articles were analyzed and future research hotspots were predicted.

results389 relevant articles were included in the analysis. The number of articles increased rapidly from 1972 to 2022, from 5 (1.3%; 1972-1982) to 208 (53.5%; 2013-2022) articles. 338 (86.9%) articles were included in relevant guidelines. According to corresponding author location, Europe was the source of the highest number of publications (183; 47.0%), followed by the Americas (152; 39.1%) and the Western Pacific (54; 13.9%). The number of publications steadily increased over time in the USA, England, Canada, Australia, Germany, and France, and surged in China and Spain, especially in the last 5 years. In recent years, endovascular therapy has accounted for the majority of ischemic stroke-related RCT articles.

conclusionsNumerous RCTs related to ischemic stroke have been conducted in recent decades, and both the number of articles and their contribution to guideline updates are increasing. Also, a shift in research topics was observed. However, great regional imbalances in this research exist, calling for more research to be conducted in specific regions to promote the generalizability of trial conclusions.

Indexed as

Ischemic StrokeRandomized Controlled Trials as TopicHumansguidelinehotspotischemic strokerandomized clinical trials

Identifiers

PMID37650337
PMCPMC11464386

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.