Evidence map›Paper›PMID 37649713›Full record

ArticleComputational and structural biotechnology journal2023

Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study.

Mateusz Jedrzejewski, Barbara Belza, Iwona Lewandowska, Marta Sadlej, Agata P Perlinska, Rafal Augustyniak, Thomas Christian, Ya-Ming Hou, Marcin Kalek, Joanna I Sulkowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mateusz JedrzejewskiCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Barbara BelzaCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Iwona LewandowskaCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Marta SadlejCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Agata P PerlinskaCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Rafal AugustyniakDepartment of Chemistry, University of Warsaw, Ludwika Pasteura 1, 02-093, Warsaw, Poland.
Thomas ChristianDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, 4201 Henry Ave, Philadelphia, PA 19144, USA.
Ya-Ming HouDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, 4201 Henry Ave, Philadelphia, PA 19144, USA.
Marcin KalekCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Joanna I SulkowskaCentre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
University of Warsaw · PLThomas Jefferson University · US

Funding

tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
NIGMS NIH HHS R35 GM134931
6 · The paper itself

Abstract

The Nep1 protein is essential for the formation of eukaryotic and archaeal small ribosomal subunits, and it catalyzes the site-directed SAM-dependent methylation of pseudouridine (Ψ) during pre-rRNA processing. It possesses a non-trivial topology, namely, a 3

Indexed as

Enzymatic catalysisMethylationNep1Proton transferRNA processingTrefoil knot

Identifiers

PMID37649713
PMCPMC10462857
OpenAlexW4385690461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.