ReviewFrontiers in cardiovascular medicine2023
Sex discrepancies in pathophysiology, presentation, treatment, and outcomes of severe aortic stenosis.
Review in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Red blood cell distribution width and blood transfusions are associated with 2-year mortality after transcatheter aortic valve implantation in males but not in females: sex-related differences in hematological predictors.Internal and emergency medicine · 2026Article
- Specificities of Aortic Stenosis in Women - From Diagnosis to Management.Saudi medical journal · 2026Review
- Comparing access to, and outcomes following, TAVI by biological sex.Open heart · 2025Article
- Global, regional, and national burden of nonrheumatic calcific aortic valve disease based on GBD study 2021.Scientific reports · 2025Article
- Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women.Structural heart : the journal of the Heart Team · 2025Review
- Sex-related differences in prosthesis-patient mismatch following aortic valve replacement with the edwards intuity valve system.Frontiers in cardiovascular medicine · 2025Article
- Burden of Mitral Regurgitation in Spain from 2016-2021: An Analysis by Aetiology and Sex.Journal of clinical medicine · 2024Article
- Sex-related disparities in aortic stenosis from disease awareness to treatment: a state-of-the-art review.Journal of thoracic disease · 2024Review
- Sex Differences in Aortic Stenosis: From the Pathophysiology to the Intervention, Current Challenges, and Future Perspectives.Journal of clinical medicine · 2024Review
- Aortic Valve Calcium Score: Applications in Clinical Practice and Scientific Research-A Narrative Review.Journal of clinical medicine · 2024Review
- Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies.Annals of medicine and surgery (2012) · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review gives an overview of sex-based differences in aortic valve stenosis, spanning from pathophysiological mechanisms and disease progression, clinical presentation, presence of comorbidities, and diagnostic assessment, to treatment and outcomes. In particular, sex-related differences in the degree of aortic valve calcification, the response of the left ventricle to pressure overload, as well as in the referral to procedures, with women being less frequently referred for surgical aortic valve replacement and experiencing longer waiting times for transcatheter procedures, will be discussed. Sex-related differences are also particularly evident in outcomes of patients with severe aortic stenosis undergoing surgical or transcatheter procedures. The apparent sex paradox seen in women undergoing transcatheter aortic valve implantation refers to the phenomenon of women experiencing higher rates of short-term mortality and bleeding events, but demonstrating improved long-term survival as compared to men. Women who undergo surgical aortic valve replacement have generally worse outcomes as compared to men, which is reflected by the inclusion of female sex in surgical risk calculation scores. Hence, a thorough understanding of sex-related differences in aortic valve stenosis is important to provide optimal and personalized patient care.
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Registered trials
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