Evidence map›Paper›PMID 37649602›Full record

ArticleTheranostics2023

Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands.

Hsiou-Ting Kuo, Zhengxing Zhang, Chengcheng Zhang, Helen Merkens, Ruiyan Tan, Antonio A W L Wong, Carlos F Uribe, François Bénard, Kuo-Shyan Lin

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hsiou-Ting KuoDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Zhengxing ZhangDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Chengcheng ZhangDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Helen MerkensDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Ruiyan TanDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Antonio A W L WongDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Carlos F UribeDepartment of Functional Imaging, BC Cancer, Vancouver, BC V5Z4E6, Canada.
François BénardDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Kuo-Shyan LinDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
University of British Columbia · CA

Funding

CIHR FDN-148465CIHR PJT-162243CIHR PJT-180299CIHR PJT-180300
6 · The paper itself

Abstract

High kidney and salivary gland uptake is a common feature of prostate-specific membrane antigen (PSMA)-targeted radioligands derived from the lysine-urea-glutamic acid (Lys-urea-Glu) pharmacophore. In this study we investigated if radioligands derived from lysine-urea-2-aminoadipic acid (Lys-urea-Aad), lysine-urea-

Indexed as

Gallium RadioisotopesLysineAlbuminsAnimalsButyric AcidHumansKidneyMaleMicePharmacophoreTissue DistributionAlbuminsButyric AcidGallium RadioisotopesLysineOff-target uptakeProstate-specific membrane antigenSalivary glandTargeted radioligand therapyTumor-to-kidney absorbed dose ratio

Identifiers

PMID37649602
PMCPMC10465233
OpenAlexW4386263679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.