Evidence map›Paper›PMID 37649398›Full record

ReviewDiabetes/metabolism research and reviews2024

Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes.

Suna Onengut-Gumuscu, Bobbie-Jo M Webb-Robertson, Soumyadeep Sarkar, Ani Manichaikul, Xiaowei Hu, Ashley Frazer-Abel, V Michael Holers, Marian J Rewers, Stephen S Rich

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes/metabolism research and reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Suna Onengut-GumuscuCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-6563-8334
Bobbie-Jo M Webb-RobertsonBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Soumyadeep SarkarBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Xiaowei HuCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0001-7804-7392
Ashley Frazer-AbelExsera BioLabs, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
V Michael HolersDivision of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Marian J RewersBarbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USPacific Northwest National Laboratory · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

Natural History of Pre-Diabetic Autoimmunity (DAISY)R01DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 1986 to 2024
$9.3M
Leona M. and Harry B. Helmsley Charitable Trust 2103-05121NIDDK NIH HHS R01 DK032493
6 · The paper itself

Abstract

Type 1 diabetes is an autoimmune disease in which one's own immune system destroys insulin-secreting beta cells in the pancreas. This process results in life-long dependence on exogenous insulin for survival. Both genetic and environmental factors play a role in disease initiation, progression, and ultimate clinical diagnosis of type 1 diabetes. This review will provide background on the natural history of type 1 diabetes and the role of genetic factors involved in the complement system, as several recent studies have identified changes in levels of these proteins as the disease evolves from pre-clinical through to clinically apparent disease.

Indexed as

Diabetes Mellitus, Type 1Insulin-Secreting CellsHumansInsulinPancreasInsulincomplement systemmajor histocompatibility complextype 1 diabetes

Identifiers

PMID37649398
PMCPMC13537109
OpenAlexW4386305975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.