Evidence map›Paper›PMID 37649323›Full record

ArticleAging cell2023

The awakening of dormant neuronal precursors in the adult and aged brain.

Bruno Benedetti, Maximilian Reisinger, Marie Hochwartner, Gabriele Gabriele, Dominika Jakubecova, Ariane Benedetti, Luca Bonfanti, Sebastien Couillard-Despres

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  8. Neuron and Brain Maturation 2.0.International journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bruno BenedettiInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-4286-5067
Maximilian ReisingerInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Marie HochwartnerInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Gabriele GabrieleInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Dominika JakubecovaInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Ariane BenedettiInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
Luca BonfantiNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.ORCID 0000-0002-1469-8898
Sebastien Couillard-DespresInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.ORCID 0000-0002-8486-6412
Paracelsus Medical University · ATNeuroscience Institute · IT

Funding

PMU Research and Innovation Fund (PMU-RIF) Seed Money for Novel Innovative Ideas and Preparat
6 · The paper itself

Abstract

Beyond the canonical neurogenic niches, there are dormant neuronal precursors in several regions of the adult mammalian brain. Dormant precursors maintain persisting post-mitotic immaturity from birth to adulthood, followed by staggered awakening, in a process that is still largely unresolved. Strikingly, due to the slow rate of awakening, some precursors remain immature until old age, which led us to question whether their awakening and maturation are affected by aging. To this end, we studied the maturation of dormant precursors in transgenic mice (DCX-CreER

Indexed as

Doublecortin ProteinNeuronsAnimalsBrainMammalsMiceMice, TransgenicMicrotubule-Associated ProteinsNeurogenesisDoublecortin ProteinMicrotubule-Associated Proteinsaction potentialaged brainaxon initial segmentdormant precursordoublecortinneurogenesisneuronal precursorsynapse

Identifiers

PMID37649323
PMCPMC10726842
OpenAlexW4386306324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.