Evidence map›Paper›PMID 37649092›Full record

Trial reportCritical care (London, England)2023

Transcutaneous electrical diaphragmatic stimulation in mechanically ventilated patients: a randomised study.

Clément Medrinal, Margaux Machefert, Bouchra Lamia, Tristan Bonnevie, Francis-Edouard Gravier, Roger Hilfiker, Guillaume Prieur, Yann Combret

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04171024 phase4completednot on this map

Transcutaneous Diaphragm Electrical StimuLAtion in Critically Ill Patients to Prevent Diaphragm Dysfunction

TypeinterventionalSponsorGroupe Hospitalier du HavreRan2019 to 2022Enrolled66ConditionsCritical Illness, Mechanical Ventilation, Intensive Care UnitArmsSham electrical stimulation, Transcutaneous diaphragm electrical stimulation
NCT06436950 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Electrical Phrenic Nerve Stimulation in Patients With Ventilator-induced Diaphragm Dysfunction: a Randomized Controlled Study

TypeinterventionalSponsorPeking University Third HospitalRan2024 to 2026Enrolled40ConditionsDiaphragms, Phrenic NervesArmstranscutaneous electrical phrenic nerve stimulation (TEPNS)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Neuromodulation in the intensive care unit.Intensive care medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clément MedrinalUniversité Paris-Saclay, UVSQ, Erphan, 78000, Versailles, France. medrinal.clement.mk@gmail.com.
Margaux MachefertUniversité Paris-Saclay, UVSQ, Erphan, 78000, Versailles, France.
Bouchra LamiaNormandie Univ, UNIROUEN, EA3830-GRHV, 76 000, Rouen, France.
Tristan BonnevieNormandie Univ, UNIROUEN, EA3830-GRHV, 76 000, Rouen, France.
Francis-Edouard GravierNormandie Univ, UNIROUEN, EA3830-GRHV, 76 000, Rouen, France.
Roger HilfikerResearch and Independent Studies in Private Physiotherapy (RISE), 3902, Brig, Switzerland.
Guillaume PrieurIntensive Care Unit Department, Le Havre Hospital, Avenue Pierre Mendes France, 76290, Montivilliers, France.
Yann CombretUniversité Paris-Saclay, UVSQ, Erphan, 78000, Versailles, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew specific methods are available to reduce the risk of diaphragmatic dysfunction for patients under mechanical ventilation. The number of studies involving transcutaneous electrical stimulation of the diaphragm (TEDS) is increasing but none report results for diaphragmatic measurements, and they lack power. We hypothesised that the use of TEDS would decrease diaphragmatic dysfunction and improve respiratory muscle strength in patients in ICU.

methodsWe conducted a controlled trial to assess the impact of daily active electrical stimulation versus sham stimulation on the prevention of diaphragm dysfunction during the weaning process from mechanical ventilation. The evaluation was based on ultrasound measurements of diaphragm thickening fraction during spontaneous breathing trials. We also measured maximal inspiratory muscle pressure (MIP), peak cough flow (PEF) and extubation failure.

resultsSixty-six patients were included and randomised using a 1:1 ratio. The mean number of days of mechanical ventilation was 10 ± 6.8. Diaphragm thickening fraction was > 30% at the SBT for 67% of participants in the TEDS group and 54% of the Sham group (OR1.55, 95% CI 0.47-5.1; p = 0.47). MIP and PEF were similar in the TEDS and Sham groups (respectively 35.5 ± 11.9 vs 29.7 ± 11.7 cmH

conclusionTEDS did not prevent diaphragm dysfunction or improve inspiratory muscle strength in mechanically ventilated patients.

trial registrationProspectively registered on the 20th November 2019 on ClinicalTrials.gov Identifier NCT04171024.

Indexed as

DiaphragmTranscutaneous Electric Nerve StimulationHumansRespiration, ArtificialRespiratory MusclesThoraxDiaphragm dysfunctionElectrical stimulationIntensive care unitMechanical ventilation

Identifiers

PMID37649092
PMCPMC10469422

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.