ArticleEuropean journal of medical research2023
Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 12 citations in OpenAlex.
- Peritoneal Incretin Deficiency and Tirzepatide as a Multi-Axis Adjuvant Hypothesis in Treatment-Refractory Endometriosis: A Mechanistic Framework Linking Metabolism, Immunity, Fibrosis, and Nociception.International journal of molecular sciences · 2026Review
- Development and external validation of a metabolic and lipid-based model for predicting subsequent pregnancy in women with endometriosis.Frontiers in immunology · 2026Article
- Applicability of ultrasound-guided puncture and laparoscopic cystectomy for ovarian endometriosis cyst: a non-randomized trial.European journal of medical research · 2025Article
- Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data.Scientific reports · 2025Article
- The Effect of Endometriosis on In Vitro Fertilization Outcomes: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2024Review
- Identification of a disulfidptosis-related genes signature for diagnostic and immune infiltration characteristics in endometriosis.Scientific reports · 2024Article
- Common Beverage Consumption and Benign Gynecological Conditions.Beverages (Basel, Switzerland) · 2024Article
- Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- Association between triglyceride-glucose index and endometriosis: results from a cross-sectional study and Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis.European journal of medical research · 2023Article
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13 authors at 1 institution in 1 country.
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Abstract
backgroundEndometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is unclear. We aimed to evaluate the characteristics of systemic metabolic indexes of endometriosis patients with infertility and their effects on pregnancy outcome after ART treatment.
methodsA retrospective cohort study involve 412 endometriosis patients and 1551 controls was conducted. Primary outcome was metabolic indexes, and secondary measures consisted of the influence of metabolic indexes on the number of retrieved oocytes and ART outcomes.
resultsEndometriosis patients had higher insulin (INS) [6.90(5.10-9.50) vs 6.50(4.80-8.90) μU/mL, P = 0.005]. A prediction model for endometriosis combining the number of previous pregnancies, CA125, fasting blood glucose (Glu) and INS, had a sensitivity of 73.9%, specificity of 67.8% and area under curve (AUC) of 0.77. There were no significant differences in ART outcomes and complications during pregnancy. The serum levels of Glu before pregnancy were associated with GDM both in endometriosis group (aOR 12.95, 95% CI 1.69-99.42, P = 0.014) and in control group (aOR 4.15, 95% CI 1.50-11.53, P = 0.006).
conclusionsWe found serum Glu is related to the number of retrieved oocytes in control group, serum INS is related to the number of retrieved oocytes in endometriosis group, while serum Glu and INS before pregnancy are related to the occurrence of GDM in two groups. A prediction model based on metabolic indexes was established, representing a promising non-invasive method to predict endometriosis patients with known pregnancy history.
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