ArticleRespiratory research2023
Quantifying ventilation by X-ray velocimetry in healthy adults.
Article in Respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Endobronchial Valve Treatment Improves Regional Specific Ventilation in the Target Lung.Respiration; international review of thoracic diseases · 2026Article
- Murine Functional Lung Imaging Using X-Ray Velocimetry for Longitudinal Noninvasive Quantitative Spatial Assessment of Pulmonary Airflow.Tomography (Ann Arbor, Mich.) · 2025Article
- X-ray velocimetry provides temporally and spatially-resolved biomarkers of lung ventilation in small airways disease.Respiratory research · 2025Article
- More accessible functional lung imaging: non-contrast CT-ventilation demonstrates strong association and agreement with PET-ventilation.Respiratory research · 2025Article
- Regional lung volume changes with noninvasive positive pressure ventilation in healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- X-ray velocimetry in dynamic imaging: a systematic overview of approaches.Polish journal of radiology · 2025Review
- Current understanding of the impact of United States military airborne hazards and burn pit exposures on respiratory health.Particle and fibre toxicology · 2024Review
- Assessment of respiratory mechanics and X-ray velocimetry functional imaging in two cystic fibrosis rat models.Scientific reports · 2024Article
- ERS International Congress 2023: highlights from the Respiratory Clinical Care and Physiology Assembly.ERJ open research · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleX-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conventional means.
objectivesTo assess agreement between XV-analysis of fluoroscopic lung images and pitot tube flowmeter measures of ventilation.
methodsXV- and pitot tube-derived ventilatory parameters were compared during tidal breathing and with bilevel-assisted breathing. Levels of agreement were assessed using the Bland-Altman analysis. Mixed models were used to characterize the association between XV- and pitot tube-derived values and optimize XV-derived values for higher ventilatory volumes. MEASUREMENTS AND MAIN
resultsTwenty-four healthy volunteers were assessed during tidal breathing and 11 were reassessed with increased minute ventilation with bilevel-assisted breathing. No clinically significant differences were observed between the two methods for respiratory rate (average Δ: 0.58; 95% limits of agreement: -1.55, 2.71) or duty cycle (average Δ: 0.02; 95% limits of agreement: 0.01, 0.03). Tidal volumes and flow rates measured using XV were lower than those measured using the pitot tube flowmeter, particularly at the higher volume ranges with bilevel-assisted breathing. Under these conditions, a mixed-model based adjustment was applied to the XV-derived values of tidal volume and flow rate to obtain closer agreement with the pitot tube-derived values.
conclusionRadiographically obtained measures of ventilation with XV demonstrate a high degree of correlation with parameters of ventilation. If the accuracy of XV were also confirmed for assessing the regional distribution of ventilation, it would provide information that goes beyond the scope of conventional pulmonary function tests or static radiographic assessments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.