ArticleMolecular biology reports2023
The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage in rats.
Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Himalayan medicinal plants for gastrointestinal disorders: ethnopharmacology and mechanistic insights.Inflammopharmacology · 2026Review
- Effects of alpha-pinene on depressive behaviors in a dextromethorphan-induced depression model in rats.Journal of Taibah University Medical Sciences · 2026Article
- The effects of alpha-pinene on anxiety behaviours and TLR4/MYD88/NF-kB pathway in the hippocampus in the reserpine-induced anxiety model in rats.Acta neuropsychiatrica · 2026Article
- Therapeutic potential of alpha-pinene in methotrexate-induced testicular toxicity: focus on apoptosis, oxidative stress, and inflammatory pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Essential Oils as Antioxidants: Mechanistic Insights from Radical Scavenging to Redox Signaling.Antioxidants (Basel, Switzerland) · 2025Review
- Myrtenal Ameliorates Ischemic Brain Injury Diabetic and Non-Diabetic Rats.Neurochemical research · 2025Article
- Alpha-pinene protects rat liver against acetaminophen-induced oxidative stress and apoptosis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Alpha Pinene Affects Intestinal Permeability and Protects the Gastrointestinal System Against Rotenone Toxicity via the Keap1/Nrf2 Pathway in Rats.Neurotoxicity research · 2025Article
- The effects of alpha-pinene against paracetamol-induced liver damage in male rats.Physiological reports · 2025Article
- Chemical Composition of Mexicali Propolis and Its Effect on Gastric Repair in an Indomethacin-Induced Gastric Injury Murine Model.Antioxidants (Basel, Switzerland) · 2025Article
- Protective effects of L-arginine on gastric ulcer induced by ethanol in rats: Modulation of oxidative stress.PloS one · 2025Article
- Can Alpha-Pinene Prevent Methotrexate-Induced Cardiac and Hepatic Damage?Physiological research · 2024Article
- Alpha-pinene ameliorate behavioral deficit induced by early postnatal hypoxia in the rat: study the inflammatory mechanism.Scientific reports · 2024Article
- Effects of fish oil on ethanol-induced gastric ulcer in rats: inflammatory responses and oxidative stress.Annals of medicine and surgery (2012) · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlpha-pinene (α-pinene) is a monoterpene with gastroprotective activity. We evaluated the gastroprotective effect of α-pinene in the gastric damage model with ethanol.
methodsWe evaluated the macroscopic evaluation of the stomach cavity, alteration in pH, mRNA expression of nuclear factor erythroid 2- related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), total antioxidant capacity (TAC) levels, and histopathological changes.
resultsPretreatment with α-pinene (10, 50 and 100 mg/kg i.p.) before oral administration of ethanol reduced gastric mucosal damage by increasing the percentage of ulcer inhibition. Alpha-pinene also increased gastric pH similar to omeprazole. In addition, the histopathological examination showed that in the groups pretreated with α-pinene 50 and 100 mg/kg, and omeprazole20 mg/kg, the lesions were less than the control group. Moreover, α- pinene 10, 50, 100, and omeprazole 20 mg/kg upregulated the NRF2 and HO1.
conclusionsOur results show that pretreatment with α-pinene is effective in reducing ethanol-induced gastric damage through regulation of Nrf2/HO-1.
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