Evidence map›Paper›PMID 37648867›Full record

ArticleNature2023

Identification of an alternative triglyceride biosynthesis pathway.

Gian-Luca McLelland, Marta Lopez-Osias, Cristy R C Verzijl, Brecht D Ellenbroek, Rafaela A Oliveira, Nicolaas J Boon, Marleen Dekker, Lisa G van den Hengel, Rahmen Ali, Hans Janssen and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 73 citations in OpenAlex.

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  12. TRMT6/TRMT61A-mediated tRNA mCellular & molecular biology letters · 2026
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  16. BAM 15 Exerts Molluscicidal Effects onMolecules (Basel, Switzerland) · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Altered Lipid Metabolism in the Vaginal Wall of Women With Pelvic Organ Prolapse: A Targeted Lipidomics Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Gian-Luca McLellandOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands. g.mclelland@nki.nl.ORCID 0000-0002-6122-6252
Marta Lopez-OsiasOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-2563-4283
Cristy R C VerzijlDepartment of Pediatrics, Section of Molecular Metabolism and Nutrition, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Brecht D EllenbroekOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0001-9987-9825
Rafaela A OliveiraOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nicolaas J BoonOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marleen DekkerOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lisa G van den HengelOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Rahmen AliAnimal Modeling Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hans JanssenElectron Microscope Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Ji-Ying SongAnimal Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Paul KrimpenfortAnimal Modeling Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Tim van ZutphenDepartment of Pediatrics, Section of Molecular Metabolism and Nutrition, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Johan W JonkerDepartment of Pediatrics, Section of Molecular Metabolism and Nutrition, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-3919-5437
Thijn R BrummelkampOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands. t.brummelkamp@nki.nl.ORCID 0000-0002-3066-7071
The Netherlands Cancer Institute · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs are associated with obesity, cardiac disease and various other pathologies

Indexed as

AcyltransferasesMembrane ProteinsTriglyceridesAnimalsCoenzyme ADiacylglycerol O-AcyltransferaseEnergy MetabolismEscherichia coliFatty AcidsHomeostasisHumansMiceNutrientsThioredoxinsAcyltransferasesCoenzyme ADGAT1 protein, humanDGAT2 protein, humanDiacylglycerol O-AcyltransferaseFatty AcidsMembrane ProteinsNutrientsThioredoxinsTMEM68 protein, humanTmem68 protein, mouseTMX1 protein, humanTriglycerides

Identifiers

PMID37648867
PMCPMC10482677
OpenAlexW4386283147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.