ArticleNature2023
Metabolic programs of T cell tissue residency empower tumour immunity.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
18.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Squalene Epoxidase: Its Regulations and Links with Cancers.International journal of molecular sciences · 2024Pooled it
- Tuning T cells to give cancer the blues.Nature immunology · 2026Article
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.Journal of extracellular vesicles · 2026Article
- Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy.Bioactive materials · 2026Article
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling.Nature medicine · 2026Article
- Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review).Oncology reports · 2026Review
- Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism.PLoS pathogens · 2026Article
- CD8MedComm · 2026Review
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.Cell · 2026Article
- Article
- Metabolic modulation of immune cell function: mechanisms and therapeutic implications in cancer immunotherapy.Oncogenesis · 2026Review
- T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026Review
- Transcription factor collaboration enables precise T cell state engineering.bioRxiv : the preprint server for biology · 2026Article
- Spatial instruction of tissue immunity.ImmunoHorizons · 2026Review
- Immunological memory to vaccines.Immunity · 2026Review
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.bioRxiv : the preprint server for biology · 2026Article
- SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.Communications biology · 2026Article
- Prior murine neurotropic coronavirus infection ameliorates experimental autoimmune encephalitis.Journal of autoimmunity · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 1 country.
Miguel Reina-CamposSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA.
Maximilian HeegSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0002-9594-1377
Kelly KennewickDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ian T MathewsLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0003-4773-7985
Giovanni GallettiSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0001-6613-2354
Vida LunaSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0002-6300-8128
Quynhanh NguyenSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA.
Hongling HuangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
J Justin MilnerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-0752-2130
Kenneth H HuDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0294-0202
Amy VichaiditDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Natalie SantillanoDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Brigid S BolandDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
John T ChangDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Mohit JainDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Sonia SharmaLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-6556-1963
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7915-3533
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9997-2496
Steven J BensingerDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-9657-4206
Ananda W GoldrathSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA. agoldrath@ucsd.edu.ORCID 0000-0002-5900-508X
University of California San Diego · USUniversity of California, Los Angeles · USLa Jolla Institute for Immunology · USSt. Jude Children's Research Hospital · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MUnderstanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2019 to 2023
$11.7MSingle-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8MT cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1MRegulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4MThe Tumor Microenvironment Niche of Type I conventional Dendritic CellsR01CA197363 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2017 to 2026
$4.5MBioactive Metabolites Modulate Immune-Related Adverse Events in Cancer ImmunotherapyR01CA256133 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI DENNIS, EDWARD A, SHARMA, SONIA · 2021 to 2025
$3.5MSystems-level identification of key regulators deciding immune cell stateR01AI150282 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2020 to 2024
$3.5MT cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0MCONTROL OF T CELL SYNAPSE STABILIZATION AND SIGNALINGR37AI052116 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2023 to 2026
$2.5MNCI NIH HHS P30 CA014195NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA197363NCI NIH HHS R01 CA256133NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R01 HL157710NIAID NIH HHS P01 AI132122NIAID NIH HHS R01 AI067545NIAID NIH HHS R01 AI072117NIAID NIH HHS R01 AI150282NIAID NIH HHS R37 AI052116NIAID NIH HHS R37 AI067545NIDDK NIH HHS P30 DK063720NIH HHS S10 OD021815NIH HHS S10 OD026929
Abstract
Tissue resident memory CD8
Indexed as
CD8-Positive T-LymphocytesLymphocytes, Tumor-InfiltratingNeoplasmsAlkyl and Aryl TransferasesAnimalsCell RespirationCholesterolHumansImmunologic MemoryIntestine, SmallMetabolomicsMevalonic AcidMiceMitochondriaSterol Regulatory Element Binding Protein 2UbiquinoneAlkyl and Aryl TransferasesCholesterolMevalonic Acidprenyl diphosphate synthase, subunit 2, humanSREBF2 protein, humanSterol Regulatory Element Binding Protein 2Ubiquinone
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.