Evidence map›Paper›PMID 37648856›Full record

ArticleNature2023

A pentameric TRPV3 channel with a dilated pore.

Shifra Lansky, John Michael Betancourt, Jingying Zhang, Yining Jiang, Elizabeth D Kim, Navid Paknejad, Crina M Nimigean, Peng Yuan, Simon Scheuring

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Symmetry-driven gating of TRPM8 by PIPNature communications · 2026
    Article
  6. Review
  7. When can AlphaFold predict the oligomeric states of proteins?Protein science : a publication of the Protein Society · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. HS-AFM Applications to Study Membrane Proteins.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shifra LanskyDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2037-7388
John Michael BetancourtDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Jingying ZhangDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
Yining JiangDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-7624-4488
Elizabeth D KimDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Navid PaknejadStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8914-7604
Crina M NimigeanDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-6254-4447
Peng YuanDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
Simon ScheuringDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. sis2019@med.cornell.edu.ORCID 0000-0003-3534-069X
Cornell University · USWashington University in St. Louis · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Enabling physical stimuli in the study of structural dynamics: The sensory ion channelsDP1AT010874 · NCCIH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHEURING, SIMON · 2019 to 2023
$5.9M
Molecular Mechanisms of Potassium Channel Permeation and GatingR01GM088352 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI NIMIGEAN, CRINA M · 2010 to 2025
$5.6M
High-speed atomic force microscopy with microsecond time resolution for the study of channels and transportersR01NS110790 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Simon Scheuring · 2019 to 2026
$2.4M
Structure and Function of a Pentameric TRPV3 ChannelR01NS134559 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Simon Scheuring · 2024 to 2026
$1.8M
STRUCTURE AND MECHANISM OF A POLYMODAL TRP ION CHANNELR01NS099341 · NINDS · WASHINGTON UNIVERSITY · PI YUAN, PENG · 2017 to 2021
$1.7M
A JEM 1400 Electron Microscope for a Core FacilityS10RR027699 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAXFIELD, FREDERICK R. · 2010 to 2010
$378k
Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channelsF32GM145091 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIM, ELIZABETH DIONE · 2022 to 2023
$139k
NCCIH NIH HHS DP1 AT010874NCI NIH HHS P30 CA008748NCRR NIH HHS S10 RR027699NIGMS NIH HHS F32 GM145091NIGMS NIH HHS R01 GM088352NINDS NIH HHS R01 NS099341NINDS NIH HHS R01 NS110790NINDS NIH HHS R01 NS134559
6 · The paper itself

Abstract

Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily that control diverse physiological functions, and therefore are attractive drug targets

Indexed as

Protein MultimerizationTRPV Cation ChannelsAnhydridesBoron CompoundsCryoelectron MicroscopyData AnalysisDiffusionMicroscopy, Atomic ForceMolecular Targeted TherapyProtein Structure, QuaternaryProtein SubunitsAnhydridesBoron CompoundsdiphenylborateProtein SubunitsTRPV Cation Channels

Identifiers

PMID37648856
PMCPMC10584365
OpenAlexW4386303203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.