ArticleNature2023
LTP induction by structural rather than enzymatic functions of CaMKII.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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74citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
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Who cites it
74 citing papers in PubMed, 110 citations in OpenAlex.
- CaMKIIα holoenzymes self-organize into chain-like mesoscale clusters.Science advances · 2026Article
- Local Synthesis of CaMKII Does Not Contribute to Activity-Dependent Generation of Ghost Boutons.eNeuro · 2026Article
- Genetic Rescue of Disrupted Synaptic Protein Interaction Network Dynamics Following SYNGAP1 Reactivation.Molecular & cellular proteomics : MCP · 2026Article
- Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning.Science advances · 2026Article
- Article
- CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low-gamma oscillations and seizure susceptibility.Epilepsia · 2026Article
- Polarized mitochondrial respiratory chain complexes in synaptic mitochondria induced by plasticity signals.Molecular and cellular biochemistry · 2026Article
- Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific frontal cortical circuit mechanisms mediating fear extinction.bioRxiv : the preprint server for biology · 2026Article
- Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation.Nature communications · 2026Article
- Article
- Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus.eLife · 2026Article
- CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability.Molecular neurobiology · 2026Review
- The perforant pathway and CA3-Schaffer collateral afferents coordinate to regulate spatial learning.Communications biology · 2026Article
- Molecular Physiology of the Neuronal Synapse.Current issues in molecular biology · 2026Review
- Cognition, Diagnosis, and Treatment of Alzheimer's Disease: A Review.Recent patents on biotechnology · 2026Review
- Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM.Nature communications · 2025Article
- Genetic rescue of disrupted synaptic protein interaction network dynamics followingbioRxiv : the preprint server for biology · 2025Article
- Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment.Nature communications · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Jonathan E Tullis *Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Matthew E Larsen *Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Nicole L RumianDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ronald K FreundDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-1850-1730
Emma E BoxerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-6190-5450
Carolyn Nicole BrownDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Steven J CoultrapDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Howard SchulmanDepartment of Neurobiology, Stanford University School of Medicine, Stanford, CA, USA.
Jason AotoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
K Ulrich BayerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. ulli.bayer@cuanschutz.edu.ORCID 0000-0003-0893-2200
University of Colorado Anschutz Medical Campus · USStanford University · US
Funding
Regulation of Calcium-permeable AMPA Receptors by AKAP79 Postsynaptic SignalingR01NS040701 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2001 to 2023
$7.7MPREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1MPostsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunctionR01NS110383 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MARK L DELL'ACQUA, Matthew J Kennedy · 2018 to 2026
$5.2MCaMKII substrate-selection in opposing forms of synaptic plasticityR01NS081248 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2013 to 2026
$4.9MCaMKII nitrosylation in the age-related decline of synaptic plasticityR01AG067713 · NIA · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH · 2020 to 2024
$2.7MCaMKII in global cerebral ischemiaR01NS080851 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2013 to 2017
$2.1MFunctional and mechanistic interrogation of alpha neurexin extracellular domainsR01MH116901 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2018 to 2022
$1.9MCaMKII in global cerebral ischemia: mechanisms and therapeutic interventionR01NS118786 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2021 to 2025
$1.9MAPP as a mediator of amyloid beta effects on CaMKII synaptic functionsF31AG084197 · NIA · UNIVERSITY OF COLORADO DENVER · PI LARSEN, MATTHEW E · 2023 to 2025
$115kMolecular computation by the CaMKII holoenzymeF31NS129254 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BROWN, CAROLYN NICOLE · 2022 to 2024
$112kCaMKII hypo-nitrosylatlon In age-related decline of synaptic plasticity and cognitionF31AG069458 · NIA · UNIVERSITY OF COLORADO DENVER · PI RUMIAN, NICOLE · 2021 to 2022
$72kSuppression of CaMKII synaptic targeting and beta-amyloid pathologyF31AG062160 · NIA · UNIVERSITY OF COLORADO DENVER · PI COOK, SARAH G · 2019 to 2020
$70kNIA NIH HHS F31 AG062160NIA NIH HHS F31 AG069458NIA NIH HHS F31 AG084197NIA NIH HHS R01 AG067713NIGMS NIH HHS T32 GM007635NIMH NIH HHS F31 MH125510NIMH NIH HHS R01 MH116901NINDS NIH HHS F31 NS129254NINDS NIH HHS R01 NS040701NINDS NIH HHS R01 NS080851NINDS NIH HHS R01 NS081248NINDS NIH HHS R01 NS110383NINDS NIH HHS R01 NS118786
Abstract
Learning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood undisputed for more than three decades is that LTP induction requires enzymatic activity of the Ca
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 2Long-Term PotentiationGlutamic AcidHippocampusLearningOptogeneticsPhosphorylationProtein BindingReceptors, N-Methyl-D-AspartateCalcium-Calmodulin-Dependent Protein Kinase Type 2Glutamic AcidNR2B NMDA receptorReceptors, N-Methyl-D-Aspartate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.