ArticleNature2023
Gut microbial carbohydrate metabolism contributes to insulin resistance.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 3 pooled it
58.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
254 citing papers in PubMed, 3 syntheses or guidelines pooled it, 382 citations in OpenAlex.
- Dietary intake of different carbohydrate types and asthma risk: a systematic review and meta-analysis.Nutrition journal · 2025Pooled it
- Implication of taxonomic abundance of gut microbiota in prediabetes: a systematic review.Frontiers in nutrition · 2025Pooled it
- Gut microbiota and type 2 diabetes associations: a meta-analysis of 16S studies and their methodological challenges.Frontiers in microbiomes · 2025Pooled it
- Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission.Nature metabolism · 2026Trial
- Trial
- Gut microbiome predicts personalized responses to dietary fiber in prediabetes: a randomized, open-label trial.Nature communications · 2025Trial
- Timing of unsaturated fat intake improves insulin sensitivity via the gut microbiota-bile acid axis: a randomized controlled trial.Nature communications · 2025Trial
- Perinatal ampicillin exposure alters murine maternal fecal bile acid and acylcarnitine profiles.Gut microbes · 2026Article
- Gut microbiome in type 2 diabetes: insights from metagenomics, multi-omics, and diet-microbe interactions.Gut microbes · 2026Review
- Gut microbiome and metabolic health: mechanisms and precision interventions.Gut microbes · 2026Review
- Association of insulin resistance indices with major adverse cardiovascular events in patients with acute myocardial infarction and chronic Kidney disease: a retrospective cohort study.Annals of medicine · 2026Article
- Dietary modulation of the gut microbiota in type 2 diabetes and obesity: mechanisms, interventions, and clinical perspectives.Acta diabetologica · 2026Review
- Grain proteins ameliorate glucose metabolism disorders by activating intestinal AhR and the hepatic NLK/FOXO1 pathway via gut microbiota-derived indole metabolites.Journal of advanced research · 2026Article
- Review
- Review
- Microbiota-Mediator-Host Signaling Networks in Metabolic Syndrome: From Mechanistic Insights to Therapeutic Targeting.Microorganisms · 2026Review
- From waste to wellness: pomelo peel derived exosome-like nanoparticles reshape gut microbiota and enhance beneficial metabolites.Food chemistry: X · 2026Article
- LECT2 deficiency contributes to bile acid metabolic reprogramming and cholestatic liver injury.Hepatology communications · 2026Article
- The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Modified Shen Ling Bai Zhu San Combined with Its Essential Oil Regulates Growth Performance, Lipid Metabolism and Intestinal Health in Silky Fowls.Animals : an open access journal from MDPI · 2026Article
194 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 14 institutions in 2 countries.
Tadashi TakeuchiLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0003-1693-7490
Tetsuya KubotaLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. kubota@oha.toho-u.ac.jp.
Yumiko NakanishiLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Hiroshi TsugawaMetabolome Informatics Research Team, RIKEN Center for Sustainable Resource Science (CSRS), Yokohama, Japan.ORCID 0000-0002-2015-3958
Wataru SudaLaboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Andrew Tae-Jun KwonLaboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Junshi YazakiLaboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0002-0697-8320
Kazutaka IkedaLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Shino NemotoLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Yoshiki MochizukiLaboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Toshimori KitamiLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0001-8418-5230
Katsuyuki YugiLaboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Yoshiko MizunoDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Nobutake YamamichiCenter for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Tsutomu YamazakiInternational University of Health and Welfare, Tokyo, Japan.ORCID 0000-0001-6510-9865
Iseki TakamotoDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Naoto KubotaDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-5428-3582
Erik ArnerLaboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0003-1225-4908
Piero CarninciLaboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0001-7202-7243
Osamu OharaLaboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0002-3328-9571
Makoto AritaLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0001-9902-0463
Masahira HattoriLaboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Shigeo KoyasuLaboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID 0000-0001-9585-3038
Hiroshi OhnoLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. hiroshi.ohno@riken.jp.ORCID 0000-0001-8776-9661
RIKEN Center for Integrative Medical Sciences · JPKazusa DNA Research Institute · JPDevelopment Bank of Japan · JPHuman Technopole · ITInternational University of Health and Welfare · JPKeio University · JPKeio University Shonan Fujisawa · JPRIKEN Center for Sustainable Resource Science · JPThe University of Tokyo · JPToho University · JPTokyo Medical University Ibaraki Medical Center · JPToranomon Hospital · JPUniversity of Tokyo Hospital · JPYokohama City University Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes
Indexed as
Carbohydrate MetabolismGastrointestinal MicrobiomeInsulin ResistanceAnimalsDiabetes Mellitus, Type 2FecesHumansInsulinMetabolic SyndromeMetabolomicsMiceMonosaccharidesInsulinMonosaccharides
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.